The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). As the c...
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doaj-c08f6f755b0d44e18e8a4bc8135f54512020-11-24T22:53:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-01-01710.3389/fnagi.2015.00001110900The Fornix in Mild Cognitive Impairment and Alzheimer’s DiseaseMilap Anil Nowrangi0Paul eRosenberg1Johns Hopkins UniversityJohns Hopkins UniversityThe fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). As the characteristic pathological processes of AD progress, structural and functional changes to the medial temporal lobes and other regions become evident years before clinical symptoms are present. Though gray matter atrophy has been the most studied, degradation of white matter structures especially the fornix may precede these and has become detectable with use of diffusion tensor imaging (DTI) and other complimentary imaging techniques. Recent research utilizing DTI measurement of the fornix has shown good discriminability of diagnostic groups, particularly early and preclinical, as well as predictive power for incident MCI and AD. Stimulating and modulating fornix function by way of DBS has been an exciting new area as pharmacological therapeutics have been slow to develop.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00001/fullDTIDBSMCIAlzheimer’sFornix |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Milap Anil Nowrangi Paul eRosenberg |
spellingShingle |
Milap Anil Nowrangi Paul eRosenberg The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease Frontiers in Aging Neuroscience DTI DBS MCI Alzheimer’s Fornix |
author_facet |
Milap Anil Nowrangi Paul eRosenberg |
author_sort |
Milap Anil Nowrangi |
title |
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease |
title_short |
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease |
title_full |
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease |
title_fullStr |
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease |
title_full_unstemmed |
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease |
title_sort |
fornix in mild cognitive impairment and alzheimer’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2015-01-01 |
description |
The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). As the characteristic pathological processes of AD progress, structural and functional changes to the medial temporal lobes and other regions become evident years before clinical symptoms are present. Though gray matter atrophy has been the most studied, degradation of white matter structures especially the fornix may precede these and has become detectable with use of diffusion tensor imaging (DTI) and other complimentary imaging techniques. Recent research utilizing DTI measurement of the fornix has shown good discriminability of diagnostic groups, particularly early and preclinical, as well as predictive power for incident MCI and AD. Stimulating and modulating fornix function by way of DBS has been an exciting new area as pharmacological therapeutics have been slow to develop. |
topic |
DTI DBS MCI Alzheimer’s Fornix |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00001/full |
work_keys_str_mv |
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