GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and i...

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Main Authors:	Steven Offenbacher, Yizu Jiao, Steven J. Kim, Julie Marchesan, Kevin L. Moss, Li Jing, Kimon Divaris, Sompop Bencharit, Cary S. Agler, Thiago Morelli, Shaoping Zhang, Lu Sun, William T. Seaman, Dale Cowley, Silvana P. Barros, James D. Beck, Matthias Munz, Arne S. Schaefer, Kari E. North
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05940-9

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spelling	doaj-c09756d6c83548c2b068a9c266188a122021-05-11T10:28:30ZengNature Publishing GroupNature Communications2041-17232018-09-019111710.1038/s41467-018-05940-9GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammationSteven Offenbacher0Yizu Jiao1Steven J. Kim2Julie Marchesan3Kevin L. Moss4Li Jing5Kimon Divaris6Sompop Bencharit7Cary S. Agler8Thiago Morelli9Shaoping Zhang10Lu Sun11William T. Seaman12Dale Cowley13Silvana P. Barros14James D. Beck15Matthias Munz16Arne S. Schaefer17Kari E. North18Department of Periodontology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Dental Ecology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Pediatric Dentistry, School of Dentistry, University of North CarolinaDepartment of General Practice, School of Dentistry, Virginia Commonwealth UniversityOral and Craniofacial Health Sciences, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaUNC Animal Models Core, University of North CarolinaDepartment of Periodontology, School of Dentistry, University of North CarolinaDepartment of Dental Ecology, School of Dentistry, University of North CarolinaDepartment of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine BerlinDepartment of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine BerlinDepartment of Epidemiology, Gillings School of Global Public Health, University of North CarolinaIL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.https://doi.org/10.1038/s41467-018-05940-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North
spellingShingle	Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation Nature Communications
author_facet	Steven Offenbacher Yizu Jiao Steven J. Kim Julie Marchesan Kevin L. Moss Li Jing Kimon Divaris Sompop Bencharit Cary S. Agler Thiago Morelli Shaoping Zhang Lu Sun William T. Seaman Dale Cowley Silvana P. Barros James D. Beck Matthias Munz Arne S. Schaefer Kari E. North
author_sort	Steven Offenbacher
title	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_short	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_full	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_fullStr	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_full_unstemmed	GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
title_sort	gwas for interleukin-1β levels in gingival crevicular fluid identifies il37 variants in periodontal inflammation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.
url	https://doi.org/10.1038/s41467-018-05940-9
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GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

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