Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer
Peptides are strings of approximately 2–50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptor...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/13/9/1433 |
id |
doaj-c09a09390d2544ec951b3c9f0d0664d6 |
---|---|
record_format |
Article |
spelling |
doaj-c09a09390d2544ec951b3c9f0d0664d62021-09-26T00:56:49ZengMDPI AGPharmaceutics1999-49232021-09-01131433143310.3390/pharmaceutics13091433Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of CancerIsha Gaurav0Xuehan Wang1Abhimanyu Thakur2Ashok Iyaswamy3Sudha Thakur4Xiaoyu Chen5Gaurav Kumar6Min Li7Zhijun Yang8School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation-CAS Limited, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaNational Institute for Locomotor Disabilities (Divyangjan), Kolkata 700090, IndiaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Basic and Applied Science, Galgotias University, Greater Noida 203201, IndiaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaPeptides are strings of approximately 2–50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptors on cancer cells, and better ability to penetrate cell membranes. The conjugation of peptides to the various nano delivery systems (NDS) has been found to provide an added benefit toward targeted delivery for cancer therapy. Moreover, the simultaneous delivery of peptide-conjugated NDS and nano probes has shown potential for the diagnosis of the malignant progression of cancer. In this review, various barriers hindering the targeting capacity of NDS are addressed, and various approaches for conjugating peptides and NDS have been discussed. Moreover, major peptide-based functionalized NDS targeting cancer-specific receptors have been considered, including the conjugation of peptides with extracellular vesicles, which are biological nanovesicles with promising ability for therapy and the diagnosis of cancer.https://www.mdpi.com/1999-4923/13/9/1433peptidecancertargeted nano deliveryextracellular vesiclestheranostic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isha Gaurav Xuehan Wang Abhimanyu Thakur Ashok Iyaswamy Sudha Thakur Xiaoyu Chen Gaurav Kumar Min Li Zhijun Yang |
spellingShingle |
Isha Gaurav Xuehan Wang Abhimanyu Thakur Ashok Iyaswamy Sudha Thakur Xiaoyu Chen Gaurav Kumar Min Li Zhijun Yang Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer Pharmaceutics peptide cancer targeted nano delivery extracellular vesicles theranostic |
author_facet |
Isha Gaurav Xuehan Wang Abhimanyu Thakur Ashok Iyaswamy Sudha Thakur Xiaoyu Chen Gaurav Kumar Min Li Zhijun Yang |
author_sort |
Isha Gaurav |
title |
Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer |
title_short |
Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer |
title_full |
Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer |
title_fullStr |
Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer |
title_full_unstemmed |
Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer |
title_sort |
peptide-conjugated nano delivery systems for therapy and diagnosis of cancer |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2021-09-01 |
description |
Peptides are strings of approximately 2–50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptors on cancer cells, and better ability to penetrate cell membranes. The conjugation of peptides to the various nano delivery systems (NDS) has been found to provide an added benefit toward targeted delivery for cancer therapy. Moreover, the simultaneous delivery of peptide-conjugated NDS and nano probes has shown potential for the diagnosis of the malignant progression of cancer. In this review, various barriers hindering the targeting capacity of NDS are addressed, and various approaches for conjugating peptides and NDS have been discussed. Moreover, major peptide-based functionalized NDS targeting cancer-specific receptors have been considered, including the conjugation of peptides with extracellular vesicles, which are biological nanovesicles with promising ability for therapy and the diagnosis of cancer. |
topic |
peptide cancer targeted nano delivery extracellular vesicles theranostic |
url |
https://www.mdpi.com/1999-4923/13/9/1433 |
work_keys_str_mv |
AT ishagaurav peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT xuehanwang peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT abhimanyuthakur peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT ashokiyaswamy peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT sudhathakur peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT xiaoyuchen peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT gauravkumar peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT minli peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer AT zhijunyang peptideconjugatednanodeliverysystemsfortherapyanddiagnosisofcancer |
_version_ |
1716869498692173824 |