Design and Synthesis of a Chiral Halogen-Bond Donor with a Sp<sup>3</sup>-Hybridized Carbon–Iodine Moiety in a Chiral Fluorobissulfonyl Scaffold
<b> </b>The first example of a chiral halogen-bond donor with a sp<sup>3</sup>-hybridized carbon–iodine moiety in a fluorobissulfonyl scaffold is described. The binaphthyl backbone was designed as a chiral source and the chiral halogen-bond donor (R)-1 was synthesized from (R...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/19/4539 |
Summary: | <b> </b>The first example of a chiral halogen-bond donor with a sp<sup>3</sup>-hybridized carbon–iodine moiety in a fluorobissulfonyl scaffold is described. The binaphthyl backbone was designed as a chiral source and the chiral halogen-bond donor (R)-1 was synthesized from (R)-1,1′-binaphthol in 11 steps. An NMR titration experiment demonstrated that (R)-1 worked as a halogen-bond donor. The Mukaiyama aldol reaction and quinoline reduction were examined using (R)-1 as a catalyst to evaluate the asymmetric induction. |
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ISSN: | 1420-3049 |