Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin

Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin

Methylglyoxal (MG) is an endogenous metabolite which ispresent in increased concentrations in diabetics and reacts withamino acids to form advanced glycation end products. In thisstudy, we investigated whether ferritin enhances DNA cleavageby the reaction of MG with lysine. When plasmid DNA wasincub...

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Bibliographic Details
Main Authors: Sung Ho An, Jung Hoon Kang
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2013-04-01
Series:BMB Reports
Subjects:
DNA
Fenton reaction
Ferritin
Methylglyoxal
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI3MTBAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni00JTVEMTMwNDI2MjA0NF8lMjgyMjUtMjI5JTI5Qk1CXzEyLTIyNS5wZGY=

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