Developing Picornaviruses for Cancer Therapy

Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including <i>Picornaviridae</i>,<i> </i>have been shown to have anticancer activity. Picornaviruses are small icosahe...

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Main Authors:	Cormac McCarthy, Nadishka Jayawardena, Laura N. Burga, Mihnea Bostina
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Cancers
Subjects:	picornavirus oncolytic virotherapy poliovirus coxsackievirus senecavirus
Online Access:	https://www.mdpi.com/2072-6694/11/5/685

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spelling	doaj-c0aaaaeda828465cb4a89c28ac9719962020-11-25T01:58:58ZengMDPI AGCancers2072-66942019-05-0111568510.3390/cancers11050685cancers11050685Developing Picornaviruses for Cancer TherapyCormac McCarthy0Nadishka Jayawardena1Laura N. Burga2Mihnea Bostina3Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New ZealandDepartment of Microbiology and Immunology, University of Otago, Dunedin 9016, New ZealandDepartment of Microbiology and Immunology, University of Otago, Dunedin 9016, New ZealandDepartment of Microbiology and Immunology, University of Otago, Dunedin 9016, New ZealandOncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including <i>Picornaviridae</i>,<i> </i>have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses<i> </i>investigated for anticancer potential and the mechanisms that underpin this specificity.https://www.mdpi.com/2072-6694/11/5/685picornavirusoncolytic virotherapypolioviruscoxsackievirussenecavirus
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cormac McCarthy Nadishka Jayawardena Laura N. Burga Mihnea Bostina
spellingShingle	Cormac McCarthy Nadishka Jayawardena Laura N. Burga Mihnea Bostina Developing Picornaviruses for Cancer Therapy Cancers picornavirus oncolytic virotherapy poliovirus coxsackievirus senecavirus
author_facet	Cormac McCarthy Nadishka Jayawardena Laura N. Burga Mihnea Bostina
author_sort	Cormac McCarthy
title	Developing Picornaviruses for Cancer Therapy
title_short	Developing Picornaviruses for Cancer Therapy
title_full	Developing Picornaviruses for Cancer Therapy
title_fullStr	Developing Picornaviruses for Cancer Therapy
title_full_unstemmed	Developing Picornaviruses for Cancer Therapy
title_sort	developing picornaviruses for cancer therapy
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2019-05-01
description	Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including <i>Picornaviridae</i>,<i> </i>have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses<i> </i>investigated for anticancer potential and the mechanisms that underpin this specificity.
topic	picornavirus oncolytic virotherapy poliovirus coxsackievirus senecavirus
url	https://www.mdpi.com/2072-6694/11/5/685
work_keys_str_mv	AT cormacmccarthy developingpicornavirusesforcancertherapy AT nadishkajayawardena developingpicornavirusesforcancertherapy AT lauranburga developingpicornavirusesforcancertherapy AT mihneabostina developingpicornavirusesforcancertherapy
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Developing Picornaviruses for Cancer Therapy

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