Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease
Background/Aims: Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial white matter tracts in Alzheimer's disease. Methods: Diffusion tensor 3T magnetic resonance imaging scans were acquired...
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doaj-c0b145d3f363495b88bb620b041176f72020-11-25T03:19:05ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642016-06-016223324110.1159/000446770446770Altered Superficial White Matter on Tractography MRI in Alzheimer's DiseaseWilliam ReginoldAngela C. LuedkeJustine ItorralbaJuan Fernandez-RuizOmar IslamAngeles GarciaBackground/Aims: Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial white matter tracts in Alzheimer's disease. Methods: Diffusion tensor 3T magnetic resonance imaging scans were acquired in 24 controls and 16 participants with Alzheimer's disease. Neuropsychological test scores were available in some participants. Tractography was performed by the Fiber Assignment by Continuous Tracking (FACT) method. The superficial white matter was manually segmented and divided into frontal, parietal, temporal and occipital lobes. The mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AxD) and fractional anisotropy (FA) of these tracts were compared between controls and participants with Alzheimer's disease and correlated with available cognitive tests while adjusting for age and white matter hyperintensity volume. Results: Alzheimer's disease was associated with increased MD (p = 0.0011), increased RD (p = 0.0019) and increased AxD (p = 0.0017) in temporal superficial white matter. In controls, superficial white matter was associated with the performance on the Montreal Cognitive Assessment, Stroop and Trail Making Test B tests, whereas in Alzheimer's disease patients, it was not associated with the performance on cognitive tests. Conclusion: Temporal lobe superficial white matter appears to be disrupted in Alzheimer's disease.http://www.karger.com/Article/FullText/446770Diffusion tensor imagingTractographyCognitive function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William Reginold Angela C. Luedke Justine Itorralba Juan Fernandez-Ruiz Omar Islam Angeles Garcia |
spellingShingle |
William Reginold Angela C. Luedke Justine Itorralba Juan Fernandez-Ruiz Omar Islam Angeles Garcia Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease Dementia and Geriatric Cognitive Disorders Extra Diffusion tensor imaging Tractography Cognitive function |
author_facet |
William Reginold Angela C. Luedke Justine Itorralba Juan Fernandez-Ruiz Omar Islam Angeles Garcia |
author_sort |
William Reginold |
title |
Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease |
title_short |
Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease |
title_full |
Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease |
title_fullStr |
Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease |
title_full_unstemmed |
Altered Superficial White Matter on Tractography MRI in Alzheimer's Disease |
title_sort |
altered superficial white matter on tractography mri in alzheimer's disease |
publisher |
Karger Publishers |
series |
Dementia and Geriatric Cognitive Disorders Extra |
issn |
1664-5464 |
publishDate |
2016-06-01 |
description |
Background/Aims: Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial white matter tracts in Alzheimer's disease. Methods: Diffusion tensor 3T magnetic resonance imaging scans were acquired in 24 controls and 16 participants with Alzheimer's disease. Neuropsychological test scores were available in some participants. Tractography was performed by the Fiber Assignment by Continuous Tracking (FACT) method. The superficial white matter was manually segmented and divided into frontal, parietal, temporal and occipital lobes. The mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AxD) and fractional anisotropy (FA) of these tracts were compared between controls and participants with Alzheimer's disease and correlated with available cognitive tests while adjusting for age and white matter hyperintensity volume. Results: Alzheimer's disease was associated with increased MD (p = 0.0011), increased RD (p = 0.0019) and increased AxD (p = 0.0017) in temporal superficial white matter. In controls, superficial white matter was associated with the performance on the Montreal Cognitive Assessment, Stroop and Trail Making Test B tests, whereas in Alzheimer's disease patients, it was not associated with the performance on cognitive tests. Conclusion: Temporal lobe superficial white matter appears to be disrupted in Alzheimer's disease. |
topic |
Diffusion tensor imaging Tractography Cognitive function |
url |
http://www.karger.com/Article/FullText/446770 |
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