Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians
Candida albicans is one of the most common fungal pathogens of humans. Prior work introduced the planarian Schmidtea mediterranea as a new model system to study the host response to fungal infection at the organismal level. In the current study, we analyzed host–pathogen changes that occurred in sit...
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doaj-c0b2e66f606d47d682dd3c09129555292021-01-14T05:49:40ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-01-011110.3389/fmicb.2020.629526629526Epithelial Infection With Candida albicans Elicits a Multi-System Response in PlanariansEli Isael Maciel0Eli Isael Maciel1Ashley Valle Arevalo2Ashley Valle Arevalo3Benjamin Ziman4Benjamin Ziman5Clarissa J. Nobile6Clarissa J. Nobile7Néstor J. Oviedo8Néstor J. Oviedo9Department of Molecular & Cell Biology, University of California, Merced, Merced, CA, United StatesQuantitative and Systems Biology Graduate Program, University of California, Merced, Merced, CA, United StatesDepartment of Molecular & Cell Biology, University of California, Merced, Merced, CA, United StatesQuantitative and Systems Biology Graduate Program, University of California, Merced, Merced, CA, United StatesDepartment of Molecular & Cell Biology, University of California, Merced, Merced, CA, United StatesQuantitative and Systems Biology Graduate Program, University of California, Merced, Merced, CA, United StatesDepartment of Molecular & Cell Biology, University of California, Merced, Merced, CA, United StatesHealth Sciences Research Institute, University of California, Merced, Merced, CA, United StatesDepartment of Molecular & Cell Biology, University of California, Merced, Merced, CA, United StatesHealth Sciences Research Institute, University of California, Merced, Merced, CA, United StatesCandida albicans is one of the most common fungal pathogens of humans. Prior work introduced the planarian Schmidtea mediterranea as a new model system to study the host response to fungal infection at the organismal level. In the current study, we analyzed host–pathogen changes that occurred in situ during early infection with C. albicans. We found that the transcription factor Bcr1 and its downstream adhesin Als3 are required for C. albicans to adhere to and colonize the planarian epithelial surface, and that adherence of C. albicans triggers a multi-system host response that is mediated by the Dectin signaling pathway. This infection response is characterized by two peaks of stem cell divisions and transcriptional changes in differentiated tissues including the nervous and the excretory systems. This response bears some resemblance to a wound-like response to physical injury; however, it takes place without visible tissue damage and it engages a distinct set of progenitor cells. Overall, we identified two C. albicans proteins that mediate epithelial infection of planarians and a comprehensive host response facilitated by diverse tissues to effectively clear the infection.https://www.frontiersin.org/articles/10.3389/fmicb.2020.629526/fullplanariansCandida albicansinfectionhost–pathogen interactionsinnate immune systemstem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eli Isael Maciel Eli Isael Maciel Ashley Valle Arevalo Ashley Valle Arevalo Benjamin Ziman Benjamin Ziman Clarissa J. Nobile Clarissa J. Nobile Néstor J. Oviedo Néstor J. Oviedo |
spellingShingle |
Eli Isael Maciel Eli Isael Maciel Ashley Valle Arevalo Ashley Valle Arevalo Benjamin Ziman Benjamin Ziman Clarissa J. Nobile Clarissa J. Nobile Néstor J. Oviedo Néstor J. Oviedo Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians Frontiers in Microbiology planarians Candida albicans infection host–pathogen interactions innate immune system stem cells |
author_facet |
Eli Isael Maciel Eli Isael Maciel Ashley Valle Arevalo Ashley Valle Arevalo Benjamin Ziman Benjamin Ziman Clarissa J. Nobile Clarissa J. Nobile Néstor J. Oviedo Néstor J. Oviedo |
author_sort |
Eli Isael Maciel |
title |
Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians |
title_short |
Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians |
title_full |
Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians |
title_fullStr |
Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians |
title_full_unstemmed |
Epithelial Infection With Candida albicans Elicits a Multi-System Response in Planarians |
title_sort |
epithelial infection with candida albicans elicits a multi-system response in planarians |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2021-01-01 |
description |
Candida albicans is one of the most common fungal pathogens of humans. Prior work introduced the planarian Schmidtea mediterranea as a new model system to study the host response to fungal infection at the organismal level. In the current study, we analyzed host–pathogen changes that occurred in situ during early infection with C. albicans. We found that the transcription factor Bcr1 and its downstream adhesin Als3 are required for C. albicans to adhere to and colonize the planarian epithelial surface, and that adherence of C. albicans triggers a multi-system host response that is mediated by the Dectin signaling pathway. This infection response is characterized by two peaks of stem cell divisions and transcriptional changes in differentiated tissues including the nervous and the excretory systems. This response bears some resemblance to a wound-like response to physical injury; however, it takes place without visible tissue damage and it engages a distinct set of progenitor cells. Overall, we identified two C. albicans proteins that mediate epithelial infection of planarians and a comprehensive host response facilitated by diverse tissues to effectively clear the infection. |
topic |
planarians Candida albicans infection host–pathogen interactions innate immune system stem cells |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2020.629526/full |
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