Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs

Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs

Cyclopeptidic chemotherapeutic prodrugs (cPCPs) are macromolecular protease-sensitive doxorubicin (DOX) prodrugs synthesized from a cyclodecapeptidic scaffold, termed Regioselectively Addressable Functionalized Template (RAFT). In order to increase the chemotherapeutic potential of DOX and limit its...

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Bibliographic Details
Main Authors: Viktorija Herceg, Jordan Bouilloux, Karolina Janikowska, Eric Allémann, Norbert Lange
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
RAFT
cathepsin B
prodrug
doxorubicin
poly (ethylene glycol)
Online Access:https://www.mdpi.com/1420-3049/25/18/4285

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