From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases
The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the prese...
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doaj-c0c3d866f5af487da8e4e4d9ebf80f0f2020-11-25T00:32:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-06-011010.3389/fendo.2019.00378459884From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative DiseasesMarco Tatullo0Marco Tatullo1Bruna Codispoti2Irina Makeeva3Caterina Benincasa4Gianrico Spagnuolo5Gianrico Spagnuolo6Biomedical Section, Tecnologica Research Institute, Crotone, ItalyDepartment of Therapeutic Dentistry, Sechenov University Russia, Moscow, RussiaBiomedical Section, Tecnologica Research Institute, Crotone, ItalyDepartment of Therapeutic Dentistry, Sechenov University Russia, Moscow, RussiaBiomedical Section, Tecnologica Research Institute, Crotone, ItalyDepartment of Therapeutic Dentistry, Sechenov University Russia, Moscow, RussiaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Università di Napoli Federico II, Naples, ItalyThe neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic about the severity of neurological diseases, such as lateral amyotrophic sclerosis and traumatic brain injuries. The aim of this mini-review is to highlight the role of neuroendocrine molecules as advantageous diagnostic and prognostic markers for both oral diseases and neurodegenerative disorders.https://www.frontiersin.org/article/10.3389/fendo.2019.00378/fulloral cancerneuroendocrine cancerpredictive markerspredictive medicineearly diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco Tatullo Marco Tatullo Bruna Codispoti Irina Makeeva Caterina Benincasa Gianrico Spagnuolo Gianrico Spagnuolo |
spellingShingle |
Marco Tatullo Marco Tatullo Bruna Codispoti Irina Makeeva Caterina Benincasa Gianrico Spagnuolo Gianrico Spagnuolo From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases Frontiers in Endocrinology oral cancer neuroendocrine cancer predictive markers predictive medicine early diagnosis |
author_facet |
Marco Tatullo Marco Tatullo Bruna Codispoti Irina Makeeva Caterina Benincasa Gianrico Spagnuolo Gianrico Spagnuolo |
author_sort |
Marco Tatullo |
title |
From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases |
title_short |
From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases |
title_full |
From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases |
title_fullStr |
From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases |
title_full_unstemmed |
From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases |
title_sort |
from mouth to brain: neuroendocrine markers play as a crosstalk among oral and neurodegenerative diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-06-01 |
description |
The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic about the severity of neurological diseases, such as lateral amyotrophic sclerosis and traumatic brain injuries. The aim of this mini-review is to highlight the role of neuroendocrine molecules as advantageous diagnostic and prognostic markers for both oral diseases and neurodegenerative disorders. |
topic |
oral cancer neuroendocrine cancer predictive markers predictive medicine early diagnosis |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00378/full |
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