Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer
Lung cancer is a malignant tumor with high metastatic ability and bone is the most common site of distant metastasis of it. However, the independent risk factors for bone metastases of lung cancer remain largely to be elucidated. Here, we conducted a retrospective study to evaluate the correlation b...
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doaj-c0c93da6ac8147f9a18542d0d67cd9102021-05-02T19:20:43ZengIOS PressTumor Biology1423-03802017-06-013910.1177/1010428317714194Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancerYang Zhou0Wen-Zhao Chen1Ai-Fen Peng2Wei-Lai Tong3Jia-Ming Liu4Zhi-Li Liu5Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, P.R. ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, P.R. ChinaSchool of Humanities, Jiangxi University of Traditional Chinese Medicine, Nanchang, P.R. ChinaDepartment of Orthopedic Surgery, People’s Hospital of Nanhai District of Foshan City, Foshan, P.R. ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, P.R. ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, P.R. ChinaLung cancer is a malignant tumor with high metastatic ability and bone is the most common site of distant metastasis of it. However, the independent risk factors for bone metastases of lung cancer remain largely to be elucidated. Here, we conducted a retrospective study to evaluate the correlation between clinical–pathological parameters, serum levels of neuron-specific enolase and CYFRA21-1, and bone metastases in lung cancer patients. The results revealed that patients with bone metastases were younger than those without metastases. Adenocarcinoma was the most frequent type of histopathology in patients with bone metastases. And the incidence of bone metastasis in patients with adenocarcinoma was significantly higher than those with other histopathological subtypes ( p < 0.001). Furthermore, the serum concentration of neuron-specific enolase was significantly higher in patients with bone lesions than those without bone metastases. Multivariate logistic regression analysis showed that patients’ age (odds ratio = 1.024, p < 0.001), concentrations of neuron-specific enolase (odds ratio = 1.212, p = 0.004), and histopathological types (odds ratio = 0.995, p = 0.001) were the independent risk factors for bone metastases in patients with lung cancer. Thus, physicians should pay attention to these factors in order to identify bone metastasis earlier while patient was primarily diagnosed as having lung cancer.https://doi.org/10.1177/1010428317714194 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Zhou Wen-Zhao Chen Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu |
spellingShingle |
Yang Zhou Wen-Zhao Chen Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer Tumor Biology |
author_facet |
Yang Zhou Wen-Zhao Chen Ai-Fen Peng Wei-Lai Tong Jia-Ming Liu Zhi-Li Liu |
author_sort |
Yang Zhou |
title |
Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
title_short |
Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
title_full |
Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
title_fullStr |
Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
title_full_unstemmed |
Neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
title_sort |
neuron-specific enolase, histopathological types, and age as risk factors for bone metastases in lung cancer |
publisher |
IOS Press |
series |
Tumor Biology |
issn |
1423-0380 |
publishDate |
2017-06-01 |
description |
Lung cancer is a malignant tumor with high metastatic ability and bone is the most common site of distant metastasis of it. However, the independent risk factors for bone metastases of lung cancer remain largely to be elucidated. Here, we conducted a retrospective study to evaluate the correlation between clinical–pathological parameters, serum levels of neuron-specific enolase and CYFRA21-1, and bone metastases in lung cancer patients. The results revealed that patients with bone metastases were younger than those without metastases. Adenocarcinoma was the most frequent type of histopathology in patients with bone metastases. And the incidence of bone metastasis in patients with adenocarcinoma was significantly higher than those with other histopathological subtypes ( p < 0.001). Furthermore, the serum concentration of neuron-specific enolase was significantly higher in patients with bone lesions than those without bone metastases. Multivariate logistic regression analysis showed that patients’ age (odds ratio = 1.024, p < 0.001), concentrations of neuron-specific enolase (odds ratio = 1.212, p = 0.004), and histopathological types (odds ratio = 0.995, p = 0.001) were the independent risk factors for bone metastases in patients with lung cancer. Thus, physicians should pay attention to these factors in order to identify bone metastasis earlier while patient was primarily diagnosed as having lung cancer. |
url |
https://doi.org/10.1177/1010428317714194 |
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