The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis.
Cardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure. However, some studies have reported different clinical and echocardiographic outcomes between male and female patients who received CRT. This Meta-analysis is to determine wh...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5409183?pdf=render |
id |
doaj-c100600ba90d46db89bfd1b68aee6189 |
---|---|
record_format |
Article |
spelling |
doaj-c100600ba90d46db89bfd1b68aee61892020-11-24T22:11:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017624810.1371/journal.pone.0176248The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis.Fa-Hui YinChun-Lei FanYa-Ya GuoHai ZhuZhi-Lu WangCardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure. However, some studies have reported different clinical and echocardiographic outcomes between male and female patients who received CRT. This Meta-analysis is to determine whether gender difference has any significant impact on clinical and echocardiographic outcomes in patients with heart failure after CRT.PubMed, Embase, and the Cochrane library database were searched. A total of 149,259 patients in 11 studies were identified. Our analysis demonstrated that women showed lower all-cause mortality than men after CRT (odds ratio[OR] 0.50, 95% confidence interval [CI] 0.36 to 0.70). No significant difference was observed in the increment of New York Heart Association (NYHA) functional class(standard mean difference[SMD] -0.07,95% CI -0.15 to 0.01), 6-minitue walk distance (6-MWD) (SMD -0.05, 95% CI -0.07 to 0.17), and quality of life (QoL) (SMD -0.10, 95% CI -0.23 to 0.03). With respect to the echocardiographic parameters, women exhibited statistically significant improvement in left ventricular ejection fraction (LVEF) (SMD 0.25,95% CI 0.07 to 0.43), and decrement of left ventricular end diastolic diameter (LVEDD) (SMD -0.27, 95% CI -0.39 to -0.25) as compared with men. No significant difference was observed in left ventricular end diastolic volume (LVEDV) (SMD -0.08, 95% CI -0.28 to 0.08) and left ventricular end systolic volume (LVESV) (SMD -0.16, 95% CI -0.40 to 0.09) between men and women.Women seem to obtain greater benefits from CRT both in clinical and echocardiographic outcomes compared with men. But as this gender superiority could be observed only during long-term follow-up periods, further studies are needed to elucidate exact reasons for this phenomenon.http://europepmc.org/articles/PMC5409183?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fa-Hui Yin Chun-Lei Fan Ya-Ya Guo Hai Zhu Zhi-Lu Wang |
spellingShingle |
Fa-Hui Yin Chun-Lei Fan Ya-Ya Guo Hai Zhu Zhi-Lu Wang The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. PLoS ONE |
author_facet |
Fa-Hui Yin Chun-Lei Fan Ya-Ya Guo Hai Zhu Zhi-Lu Wang |
author_sort |
Fa-Hui Yin |
title |
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. |
title_short |
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. |
title_full |
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. |
title_fullStr |
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. |
title_full_unstemmed |
The impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: A systematic review and meta-analysis. |
title_sort |
impact of gender difference on clinical and echocardiographic outcomes in patients with heart failure after cardiac resynchronization therapy: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Cardiac resynchronization therapy(CRT) has been recommended as a standard treatment for patients with advanced heart failure. However, some studies have reported different clinical and echocardiographic outcomes between male and female patients who received CRT. This Meta-analysis is to determine whether gender difference has any significant impact on clinical and echocardiographic outcomes in patients with heart failure after CRT.PubMed, Embase, and the Cochrane library database were searched. A total of 149,259 patients in 11 studies were identified. Our analysis demonstrated that women showed lower all-cause mortality than men after CRT (odds ratio[OR] 0.50, 95% confidence interval [CI] 0.36 to 0.70). No significant difference was observed in the increment of New York Heart Association (NYHA) functional class(standard mean difference[SMD] -0.07,95% CI -0.15 to 0.01), 6-minitue walk distance (6-MWD) (SMD -0.05, 95% CI -0.07 to 0.17), and quality of life (QoL) (SMD -0.10, 95% CI -0.23 to 0.03). With respect to the echocardiographic parameters, women exhibited statistically significant improvement in left ventricular ejection fraction (LVEF) (SMD 0.25,95% CI 0.07 to 0.43), and decrement of left ventricular end diastolic diameter (LVEDD) (SMD -0.27, 95% CI -0.39 to -0.25) as compared with men. No significant difference was observed in left ventricular end diastolic volume (LVEDV) (SMD -0.08, 95% CI -0.28 to 0.08) and left ventricular end systolic volume (LVESV) (SMD -0.16, 95% CI -0.40 to 0.09) between men and women.Women seem to obtain greater benefits from CRT both in clinical and echocardiographic outcomes compared with men. But as this gender superiority could be observed only during long-term follow-up periods, further studies are needed to elucidate exact reasons for this phenomenon. |
url |
http://europepmc.org/articles/PMC5409183?pdf=render |
work_keys_str_mv |
AT fahuiyin theimpactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT chunleifan theimpactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT yayaguo theimpactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT haizhu theimpactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT zhiluwang theimpactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT fahuiyin impactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT chunleifan impactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT yayaguo impactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT haizhu impactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis AT zhiluwang impactofgenderdifferenceonclinicalandechocardiographicoutcomesinpatientswithheartfailureaftercardiacresynchronizationtherapyasystematicreviewandmetaanalysis |
_version_ |
1725805628053520384 |