Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making
Decision making is a cognitive function relaying on a complex neural network. In particular, the right dorsolateral prefrontal cortex (DLPFC) plays a key role within this network. We used positron emission tomography (PET) combined with continuous theta burst transcranial magnetic stimulation (cTBS)...
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doaj-c10ed6ddf96b4162a6c14402315d504d2021-03-18T04:35:49ZengElsevierBrain Stimulation1935-861X2012-04-0152116123Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision makingSang Soo Cho0Giovanna Pellecchia1Ji Hyun Ko2Nicola Ray3Ignacio Obeso4Sylvain Houle5Antonio P. Strafella6Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, CanadaImaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, CanadaDivision of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada; Imaging Research Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Corresponding author.Decision making is a cognitive function relaying on a complex neural network. In particular, the right dorsolateral prefrontal cortex (DLPFC) plays a key role within this network. We used positron emission tomography (PET) combined with continuous theta burst transcranial magnetic stimulation (cTBS) to investigate neuronal and behavioral changes in normal volunteers while performing a delay discounting (DD) task. We aimed to test whether stimulation of right DLPFC would modify the activation pattern of the neural circuit underlying decision making during the DD task and influence discounting behavior.We found that cTBS of the right DLPFC influenced decision making by reducing impulsivity and inducing participants to favor large but delayed rewards instead of immediate but small rewards. Stimulation also affected activation in several prefrontal areas associated with DD. In particular, we observed a reduced regional cerebral blood flow (rCBF) in the ipsilateral DLPFC (BA 46) extending into the rostral part of the prefrontal cortex (BA 10) as well as a disrupted relationship between impulsivity (k-value) and rCBF in these and other prefrontal areas.These findings suggest that transcranial magnetic stimulation of the DLPFC influences the neural network underlying impulsive decision making behavior.http://www.sciencedirect.com/science/article/pii/S1935861X12000307rTMSTheta burst stimulationDorsolateral prefrontal cortexDecision makingImpulsivityDelay discounting task |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sang Soo Cho Giovanna Pellecchia Ji Hyun Ko Nicola Ray Ignacio Obeso Sylvain Houle Antonio P. Strafella |
spellingShingle |
Sang Soo Cho Giovanna Pellecchia Ji Hyun Ko Nicola Ray Ignacio Obeso Sylvain Houle Antonio P. Strafella Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making Brain Stimulation rTMS Theta burst stimulation Dorsolateral prefrontal cortex Decision making Impulsivity Delay discounting task |
author_facet |
Sang Soo Cho Giovanna Pellecchia Ji Hyun Ko Nicola Ray Ignacio Obeso Sylvain Houle Antonio P. Strafella |
author_sort |
Sang Soo Cho |
title |
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
title_short |
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
title_full |
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
title_fullStr |
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
title_full_unstemmed |
Effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
title_sort |
effect of continuous theta burst stimulation of the right dorsolateral prefrontal cortex on cerebral blood flow changes during decision making |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2012-04-01 |
description |
Decision making is a cognitive function relaying on a complex neural network. In particular, the right dorsolateral prefrontal cortex (DLPFC) plays a key role within this network. We used positron emission tomography (PET) combined with continuous theta burst transcranial magnetic stimulation (cTBS) to investigate neuronal and behavioral changes in normal volunteers while performing a delay discounting (DD) task. We aimed to test whether stimulation of right DLPFC would modify the activation pattern of the neural circuit underlying decision making during the DD task and influence discounting behavior.We found that cTBS of the right DLPFC influenced decision making by reducing impulsivity and inducing participants to favor large but delayed rewards instead of immediate but small rewards. Stimulation also affected activation in several prefrontal areas associated with DD. In particular, we observed a reduced regional cerebral blood flow (rCBF) in the ipsilateral DLPFC (BA 46) extending into the rostral part of the prefrontal cortex (BA 10) as well as a disrupted relationship between impulsivity (k-value) and rCBF in these and other prefrontal areas.These findings suggest that transcranial magnetic stimulation of the DLPFC influences the neural network underlying impulsive decision making behavior. |
topic |
rTMS Theta burst stimulation Dorsolateral prefrontal cortex Decision making Impulsivity Delay discounting task |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X12000307 |
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