MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions
Background: Several previous reports of anaplastic ependymomas have described their imaging features, and most of these studies were case reports. However, no studies have compared the magnetic resonance imaging (MRI) features between the infratentorial and supratentorial anaplastic ependymomas.Obje...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-07-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01063/full |
id |
doaj-c11eccd24cd6492b9e36ac354c9ebd51 |
---|---|
record_format |
Article |
spelling |
doaj-c11eccd24cd6492b9e36ac354c9ebd512020-11-25T02:49:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-07-011010.3389/fonc.2020.01063546997MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial LesionsXin-Ping Kuai0Sheng-Yu Wang1Yi-Ping Lu2Ji Xiong3Dao-Ying Geng4Bo Yin5Department of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaBackground: Several previous reports of anaplastic ependymomas have described their imaging features, and most of these studies were case reports. However, no studies have compared the magnetic resonance imaging (MRI) features between the infratentorial and supratentorial anaplastic ependymomas.Objective: The goal of this study was to explore MRI characteristics for intracranial anaplastic ependymomas.Material and Methods: We retrospectively reviewed the demographics of 165 patients and MRI findings of 60 patients with supratentorial (SAEs) and infratentorial anaplastic ependymomas (IAEs) before surgery. The demographics and MRI features for SAEs and IAEs were compared and evaluated.Results: Among the 60 patients, most SAEs (91.7%) were extraventricular, whereas most IAEs (91.7%) were intraventricular. Of sixty intracranial anaplastic ependymomas, most lesions were well-defined (n = 45) and round-like (n = 36). On T1-weighted imaging, compared with the gray matter, the SAEs exhibited heterogeneous signal intensity, whereas IAEs exhibited iso-hypointense signals. T2 signals exhibited greater associations with hyperintense signals in IAEs; however, SAEs showed hyperintense or hypointense–hyperintense. On diffusion-weighted imaging (DWI), almost all solid tissues of SAEs appeared as hyperintense, whereas IAEs exhibited iso-hypointense signals. Peritumoral edema and intratumoral hemorrhage occurred more frequently in SAEs. Almost all anaplastic ependymomas exhibited heterogeneous enhancement. Cysts or necrosis was associated with 56 anaplastic ependymomas; however, large cysts were more prevalent in SAEs. On magnetic resonance spectroscopy (MRS), the mean choline/creatine (Cho/Cr) and choline/N-acetyl-aspartate (Cho/NAA) ratio of anaplastic ependymomas were (6.58 ± 4.26) and (8.84 ± 6.34), respectively, representing typical high-grade tumors.Conclusion: We demonstrate the conventional and functional MRI features of intracranial anaplastic ependymomas, including DWI and MRS. MRI characteristics, such as location, cyst, diffusion restriction, and peritumoral edema, differed between supratentorial and infratentorial locations. Cho/Cr and Cho/ NAA ratios of anaplastic ependymomas are increased.https://www.frontiersin.org/article/10.3389/fonc.2020.01063/fullanaplastic ependymomasintracranialsupratentorialinfratentorialmagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin-Ping Kuai Sheng-Yu Wang Yi-Ping Lu Ji Xiong Dao-Ying Geng Bo Yin |
spellingShingle |
Xin-Ping Kuai Sheng-Yu Wang Yi-Ping Lu Ji Xiong Dao-Ying Geng Bo Yin MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions Frontiers in Oncology anaplastic ependymomas intracranial supratentorial infratentorial magnetic resonance imaging |
author_facet |
Xin-Ping Kuai Sheng-Yu Wang Yi-Ping Lu Ji Xiong Dao-Ying Geng Bo Yin |
author_sort |
Xin-Ping Kuai |
title |
MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions |
title_short |
MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions |
title_full |
MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions |
title_fullStr |
MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions |
title_full_unstemmed |
MRI Features of Intracranial Anaplastic Ependymomas: A Comparison of Supratentorial and Infratentorial Lesions |
title_sort |
mri features of intracranial anaplastic ependymomas: a comparison of supratentorial and infratentorial lesions |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-07-01 |
description |
Background: Several previous reports of anaplastic ependymomas have described their imaging features, and most of these studies were case reports. However, no studies have compared the magnetic resonance imaging (MRI) features between the infratentorial and supratentorial anaplastic ependymomas.Objective: The goal of this study was to explore MRI characteristics for intracranial anaplastic ependymomas.Material and Methods: We retrospectively reviewed the demographics of 165 patients and MRI findings of 60 patients with supratentorial (SAEs) and infratentorial anaplastic ependymomas (IAEs) before surgery. The demographics and MRI features for SAEs and IAEs were compared and evaluated.Results: Among the 60 patients, most SAEs (91.7%) were extraventricular, whereas most IAEs (91.7%) were intraventricular. Of sixty intracranial anaplastic ependymomas, most lesions were well-defined (n = 45) and round-like (n = 36). On T1-weighted imaging, compared with the gray matter, the SAEs exhibited heterogeneous signal intensity, whereas IAEs exhibited iso-hypointense signals. T2 signals exhibited greater associations with hyperintense signals in IAEs; however, SAEs showed hyperintense or hypointense–hyperintense. On diffusion-weighted imaging (DWI), almost all solid tissues of SAEs appeared as hyperintense, whereas IAEs exhibited iso-hypointense signals. Peritumoral edema and intratumoral hemorrhage occurred more frequently in SAEs. Almost all anaplastic ependymomas exhibited heterogeneous enhancement. Cysts or necrosis was associated with 56 anaplastic ependymomas; however, large cysts were more prevalent in SAEs. On magnetic resonance spectroscopy (MRS), the mean choline/creatine (Cho/Cr) and choline/N-acetyl-aspartate (Cho/NAA) ratio of anaplastic ependymomas were (6.58 ± 4.26) and (8.84 ± 6.34), respectively, representing typical high-grade tumors.Conclusion: We demonstrate the conventional and functional MRI features of intracranial anaplastic ependymomas, including DWI and MRS. MRI characteristics, such as location, cyst, diffusion restriction, and peritumoral edema, differed between supratentorial and infratentorial locations. Cho/Cr and Cho/ NAA ratios of anaplastic ependymomas are increased. |
topic |
anaplastic ependymomas intracranial supratentorial infratentorial magnetic resonance imaging |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.01063/full |
work_keys_str_mv |
AT xinpingkuai mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions AT shengyuwang mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions AT yipinglu mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions AT jixiong mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions AT daoyinggeng mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions AT boyin mrifeaturesofintracranialanaplasticependymomasacomparisonofsupratentorialandinfratentoriallesions |
_version_ |
1724744503945854976 |