Effect of catch-up growth after food restriction on the entero-insular axis in rats
<p>Abstract</p> <p>Background</p> <p>Catch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered fun...
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doaj-c1203584f48d490c86db82630a2f5de52020-11-24T22:06:24ZengBMCNutrition & Metabolism1743-70752010-05-01714510.1186/1743-7075-7-45Effect of catch-up growth after food restriction on the entero-insular axis in ratsKong WenHu XiangZheng JuanYang Wei-HongChen Lu-LuZhang Hao-Hao<p>Abstract</p> <p>Background</p> <p>Catch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered functions of pancreatic islets.</p> <p>Methods</p> <p>Experimental rats were divided into two groups. Rats in CUGFR group were put on food-restriction for 4 weeks, and then allowed full access to food for 0, 2, 4 weeks respectively while rats in the control group were offered <it>ad libitum </it>access to food. Plasma glucose, insulin and GLP-1 level during OGTT were measured in all the rats. Moreover, morphology of intestinal mucosa, number of L cells, beta cell mass, incretin effect and the expression of GLP-1 receptor (GLP-1R) gene in the islets were also determined.</p> <p>Results</p> <p>The size of pancreatic islets, insulin concentration, plasma GLP-1 concentration, incretin effect, villus height-to-crypt depth ratio and L cells were all significantly decreased in CUGFR group at the end of a 4-week food-restriction period as compared with the controls. Insulin concentration and the villus height-to-crypt depth ratio were increased and finally exceeded the level of the control group over a 4-week catch-up period. Nevertheless, at the conclusion of the study, islet size, L cells number, plasma GLP-1 concentration and incretin effect increased but failed to reach the levels of the controls.</p> <p>Conclusion</p> <p>CUGFR decreases incretin effect and disturbs the entero-insular axis partially by decreasing GLP-1 concentration, which might be responsible for the increased risk of metabolic disorder during CUGFR.</p> http://www.nutritionandmetabolism.com/content/7/1/45 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kong Wen Hu Xiang Zheng Juan Yang Wei-Hong Chen Lu-Lu Zhang Hao-Hao |
spellingShingle |
Kong Wen Hu Xiang Zheng Juan Yang Wei-Hong Chen Lu-Lu Zhang Hao-Hao Effect of catch-up growth after food restriction on the entero-insular axis in rats Nutrition & Metabolism |
author_facet |
Kong Wen Hu Xiang Zheng Juan Yang Wei-Hong Chen Lu-Lu Zhang Hao-Hao |
author_sort |
Kong Wen |
title |
Effect of catch-up growth after food restriction on the entero-insular axis in rats |
title_short |
Effect of catch-up growth after food restriction on the entero-insular axis in rats |
title_full |
Effect of catch-up growth after food restriction on the entero-insular axis in rats |
title_fullStr |
Effect of catch-up growth after food restriction on the entero-insular axis in rats |
title_full_unstemmed |
Effect of catch-up growth after food restriction on the entero-insular axis in rats |
title_sort |
effect of catch-up growth after food restriction on the entero-insular axis in rats |
publisher |
BMC |
series |
Nutrition & Metabolism |
issn |
1743-7075 |
publishDate |
2010-05-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Catch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered functions of pancreatic islets.</p> <p>Methods</p> <p>Experimental rats were divided into two groups. Rats in CUGFR group were put on food-restriction for 4 weeks, and then allowed full access to food for 0, 2, 4 weeks respectively while rats in the control group were offered <it>ad libitum </it>access to food. Plasma glucose, insulin and GLP-1 level during OGTT were measured in all the rats. Moreover, morphology of intestinal mucosa, number of L cells, beta cell mass, incretin effect and the expression of GLP-1 receptor (GLP-1R) gene in the islets were also determined.</p> <p>Results</p> <p>The size of pancreatic islets, insulin concentration, plasma GLP-1 concentration, incretin effect, villus height-to-crypt depth ratio and L cells were all significantly decreased in CUGFR group at the end of a 4-week food-restriction period as compared with the controls. Insulin concentration and the villus height-to-crypt depth ratio were increased and finally exceeded the level of the control group over a 4-week catch-up period. Nevertheless, at the conclusion of the study, islet size, L cells number, plasma GLP-1 concentration and incretin effect increased but failed to reach the levels of the controls.</p> <p>Conclusion</p> <p>CUGFR decreases incretin effect and disturbs the entero-insular axis partially by decreasing GLP-1 concentration, which might be responsible for the increased risk of metabolic disorder during CUGFR.</p> |
url |
http://www.nutritionandmetabolism.com/content/7/1/45 |
work_keys_str_mv |
AT kongwen effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats AT huxiang effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats AT zhengjuan effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats AT yangweihong effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats AT chenlulu effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats AT zhanghaohao effectofcatchupgrowthafterfoodrestrictionontheenteroinsularaxisinrats |
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