Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study
Abstract Background A number of studies have examined the association between mold exposure and childhood asthma. However, the conclusions were inconsistent, which might be partly attributable to the lack of consideration of gene function, especially the key genes affecting the pathogenesis of child...
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doaj-c121aa4ed7314dce82873daf5c5c635e2021-04-04T11:26:42ZengBMCBMC Pulmonary Medicine1471-24662021-04-0121111110.1186/s12890-021-01484-9Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control studyYu Zhang0Li Hua1Quan-Hua Liu2Shu-Yuan Chu3Yue-Xin Gan4Min Wu5Yi-Xiao Bao6Qian Chen7Jun Zhang8Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, School of Public Health, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineLaboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical UniversityMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Chinese Traditional Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatric Pulmonology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, School of Public Health, Shanghai Jiao Tong University School of MedicineAbstract Background A number of studies have examined the association between mold exposure and childhood asthma. However, the conclusions were inconsistent, which might be partly attributable to the lack of consideration of gene function, especially the key genes affecting the pathogenesis of childhood asthma. Research on the interactions between genes and mold exposure on childhood asthma is still very limited. We therefore examined whether there is an interaction between inflammation-related genes and mold exposure on childhood asthma. Methods A case–control study with 645 asthmatic children and 910 non-asthmatic children aged 3–12 years old was conducted. Eight single nucleotide polymorphisms (SNPs) in inflammation-related genes were genotyped using MassARRAY assay. Mold exposure was defined as self-reported visible mold on the walls. Associations between visible mold exposure, SNPs and childhood asthma were evaluated using logistic regression models. In addition, crossover analyses were used to estimate the gene-environment interactions on childhood asthma on an additive scale. Results After excluding children without information on visible mold exposure or SNPs, 608 asthmatic and 839 non-asthmatic children were included in the analyses. Visible mold exposure was reported in 151 asthmatic (24.8%) and 119 non-asthmatic children (14.2%) (aOR 2.19, 95% CI 1.62–2.97). The rs7216389 SNP in gasdermin B gene (GSDMB) increased the risk of childhood asthma with each C to T substitution in a dose-dependent pattern (additive model, aOR 1.32, 95% CI 1.11–1.57). Children carrying the rs7216389 T allele and exposed to visible mold dramatically increased the risk of childhood asthma (aOR 3.21; 95% CI 1.77–5.99). The attributable proportion due to the interaction (AP: 0.47, 95% CI 0.03–0.90) and the relative excess risk due to the interaction (RERI: 1.49, 95% CI 0–2.99) were statistically significant. Conclusions In the present study, there was a significant additive interaction between visible mold exposure and rs7216389 SNP on childhood asthma. Future studies need to consider the gene-environment interactions when exploring the risk factors of childhood asthma.https://doi.org/10.1186/s12890-021-01484-9MoldAdditive interactionRs7216389Single nucleotide polymorphismsChildhood asthma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Zhang Li Hua Quan-Hua Liu Shu-Yuan Chu Yue-Xin Gan Min Wu Yi-Xiao Bao Qian Chen Jun Zhang |
spellingShingle |
Yu Zhang Li Hua Quan-Hua Liu Shu-Yuan Chu Yue-Xin Gan Min Wu Yi-Xiao Bao Qian Chen Jun Zhang Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study BMC Pulmonary Medicine Mold Additive interaction Rs7216389 Single nucleotide polymorphisms Childhood asthma |
author_facet |
Yu Zhang Li Hua Quan-Hua Liu Shu-Yuan Chu Yue-Xin Gan Min Wu Yi-Xiao Bao Qian Chen Jun Zhang |
author_sort |
Yu Zhang |
title |
Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
title_short |
Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
title_full |
Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
title_fullStr |
Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
title_full_unstemmed |
Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
title_sort |
household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2021-04-01 |
description |
Abstract Background A number of studies have examined the association between mold exposure and childhood asthma. However, the conclusions were inconsistent, which might be partly attributable to the lack of consideration of gene function, especially the key genes affecting the pathogenesis of childhood asthma. Research on the interactions between genes and mold exposure on childhood asthma is still very limited. We therefore examined whether there is an interaction between inflammation-related genes and mold exposure on childhood asthma. Methods A case–control study with 645 asthmatic children and 910 non-asthmatic children aged 3–12 years old was conducted. Eight single nucleotide polymorphisms (SNPs) in inflammation-related genes were genotyped using MassARRAY assay. Mold exposure was defined as self-reported visible mold on the walls. Associations between visible mold exposure, SNPs and childhood asthma were evaluated using logistic regression models. In addition, crossover analyses were used to estimate the gene-environment interactions on childhood asthma on an additive scale. Results After excluding children without information on visible mold exposure or SNPs, 608 asthmatic and 839 non-asthmatic children were included in the analyses. Visible mold exposure was reported in 151 asthmatic (24.8%) and 119 non-asthmatic children (14.2%) (aOR 2.19, 95% CI 1.62–2.97). The rs7216389 SNP in gasdermin B gene (GSDMB) increased the risk of childhood asthma with each C to T substitution in a dose-dependent pattern (additive model, aOR 1.32, 95% CI 1.11–1.57). Children carrying the rs7216389 T allele and exposed to visible mold dramatically increased the risk of childhood asthma (aOR 3.21; 95% CI 1.77–5.99). The attributable proportion due to the interaction (AP: 0.47, 95% CI 0.03–0.90) and the relative excess risk due to the interaction (RERI: 1.49, 95% CI 0–2.99) were statistically significant. Conclusions In the present study, there was a significant additive interaction between visible mold exposure and rs7216389 SNP on childhood asthma. Future studies need to consider the gene-environment interactions when exploring the risk factors of childhood asthma. |
topic |
Mold Additive interaction Rs7216389 Single nucleotide polymorphisms Childhood asthma |
url |
https://doi.org/10.1186/s12890-021-01484-9 |
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