On multi-marker tests for association in case-control studies

Genome-wide association studies (GWAs) have identified thousands of DNA loci associated with a variety of traits. Statistical inference is almost always based on single marker hypothesis tests of association and the respective p-values with Bonferroni correction. Since commercially available genomic...

Full description

Bibliographic Details
Main Authors: Margaret A Taub, Holger R Schwender, Samuel G Younkin, Thomas A Louis, Ingo eRuczinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00252/full