Genome-wide analysis of therapeutic response uncovers molecular pathways governing tamoxifen resistance in ER+ breast cancer

Genome-wide analysis of therapeutic response uncovers molecular pathways governing tamoxifen resistance in ER+ breast cancer

Background: Prioritization of breast cancer patients based on the risk of resistance to tamoxifen plays a significant role in personalized therapeutic planning and improving disease course and outcomes. Methods: In this work, we demonstrate that a genome-wide pathway-centric computational framework...

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Bibliographic Details
Main Authors: Sarra M. Rahem, Nusrat J. Epsi, Frederick D. Coffman, Antonina Mitrofanova
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:EBioMedicine
Subjects:
Therapeutic resistance
Pathway markers
Tamoxifen
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420304230

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