Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

Bibliographic Details
Main Authors:	Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A. Nedospasov, Edward E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14091

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spelling	doaj-c1280a37456c4ba7b643279d85e82d642021-05-11T07:15:24ZengNature Publishing GroupNature Communications2041-17232017-03-018111410.1038/ncomms14091Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNFXusheng Wang0Haiyan Chen1Ruiyun Tian2Yiling Zhang3Marina S. Drutskaya4Chengmei Wang5Jianfeng Ge6Zhimeng Fan7Deqiang Kong8Xiaoxiao Wang9Ting Cai10Ying Zhou11Jingwen Wang12Jinmei Wang13Shan Wang14Zhihai Qin15Huanhuan Jia16Yue Wu17Jia Liu18Sergei A. Nedospasov19Edward E. Tredget20Mei Lin21Jianjun Liu22Yuyang Jiang23Yaojiong Wu24School of Life Sciences, Tsinghua UniversityThe Shenzhen Key Laboratory of Health Sciences and TechnologyThe Shenzhen Key Laboratory of Health Sciences and TechnologyDepartment of Orthopedics, The General Hospital of Chinese People's Liberation ArmyEngelhardt Institute of Molecular Biology, Russian Academy of SciencesSchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversityInstitute of Biophysics, Chinese Academy of SciencesGuangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory AnimalsGuangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory AnimalsCollege of Life Sciences, Northeast Forestry UniversityEngelhardt Institute of Molecular Biology, Russian Academy of SciencesDepartment of Surgery, Wound Healing Research Group, University of AlbertaThe Shenzhen Key Laboratory of Health Sciences and TechnologyMedical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and PreventionState Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua UniversityThe Shenzhen Key Laboratory of Health Sciences and TechnologyHair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.https://doi.org/10.1038/ncomms14091
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu
spellingShingle	Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF Nature Communications
author_facet	Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu
author_sort	Xusheng Wang
title	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_short	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_full	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_fullStr	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_full_unstemmed	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_sort	macrophages induce akt/β-catenin-dependent lgr5+ stem cell activation and hair follicle regeneration through tnf
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-03-01
description	Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.
url	https://doi.org/10.1038/ncomms14091
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Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

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