Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review)
The review devoted to sorbents and sorbentbased medical devices used in clinical practice for extracorporeal detoxification using a hemoperfusion technique. Clinical data have confirmed the effectiveness of this approach for removal of bacterial endotoxins, lowdensity lipoproteins, and bilirubin. Ot...
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Russian Academy of Medical Sciences
2017-01-01
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doaj-c1292f3f5bde4d75ab42b1e7f1c880382021-07-28T21:21:56ZrusRussian Academy of Medical SciencesObŝaâ Reanimatologiâ1813-97792411-71102017-01-011268210710.15360/1813-9779-2016-6-82-1071538Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review)A. S. Morozov0I. V. Bessonov1A. V. Nuzhdina2V. M. Pisarev3JSC “Advanced Medical Technologies”JSC “Advanced Medical Technologies”Bauman Moscow State Technical UniversityV. A. Negovsky Research Institute of General ReanimatologyThe review devoted to sorbents and sorbentbased medical devices used in clinical practice for extracorporeal detoxification using a hemoperfusion technique. Clinical data have confirmed the effectiveness of this approach for removal of bacterial endotoxins, lowdensity lipoproteins, and bilirubin. Other studies demonstrated successful application of sorbents to treat autoimmune diseases. Special attention is paid to hemoperfusion in as a possible treatment for severe sepsis and septic shock. The review justifies importance of development and application of novel multimodal sorbents, which combine both properties of selective and nonselective sorbents. The review discusses clinical efficacy of hemoperfusion and key molecular interactions between the sorbent and circulating molecules pathogenetically relevant to developing critical illness and severe diseases. The reference list: 137.https://www.reanimatology.com/rmt/article/view/1564sorbentplasmasorbenthemoperfusionabsorbing polymer materialsepsisextracorporeal therapy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. S. Morozov I. V. Bessonov A. V. Nuzhdina V. M. Pisarev |
spellingShingle |
A. S. Morozov I. V. Bessonov A. V. Nuzhdina V. M. Pisarev Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) Obŝaâ Reanimatologiâ sorbent plasmasorbent hemoperfusion absorbing polymer material sepsis extracorporeal therapy |
author_facet |
A. S. Morozov I. V. Bessonov A. V. Nuzhdina V. M. Pisarev |
author_sort |
A. S. Morozov |
title |
Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) |
title_short |
Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) |
title_full |
Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) |
title_fullStr |
Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) |
title_full_unstemmed |
Sorbents for Extracorporeal Removal of Toxic Substances and Molecules with Adverse Biological Activity (Review) |
title_sort |
sorbents for extracorporeal removal of toxic substances and molecules with adverse biological activity (review) |
publisher |
Russian Academy of Medical Sciences |
series |
Obŝaâ Reanimatologiâ |
issn |
1813-9779 2411-7110 |
publishDate |
2017-01-01 |
description |
The review devoted to sorbents and sorbentbased medical devices used in clinical practice for extracorporeal detoxification using a hemoperfusion technique. Clinical data have confirmed the effectiveness of this approach for removal of bacterial endotoxins, lowdensity lipoproteins, and bilirubin. Other studies demonstrated successful application of sorbents to treat autoimmune diseases. Special attention is paid to hemoperfusion in as a possible treatment for severe sepsis and septic shock. The review justifies importance of development and application of novel multimodal sorbents, which combine both properties of selective and nonselective sorbents. The review discusses clinical efficacy of hemoperfusion and key molecular interactions between the sorbent and circulating molecules pathogenetically relevant to developing critical illness and severe diseases. The reference list: 137. |
topic |
sorbent plasmasorbent hemoperfusion absorbing polymer material sepsis extracorporeal therapy |
url |
https://www.reanimatology.com/rmt/article/view/1564 |
work_keys_str_mv |
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_version_ |
1721259740600729600 |