Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism.
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity...
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2018-01-01
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doaj-c12d1b1b610c42739c0b1386834c16c62020-11-25T00:26:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01132e019118210.1371/journal.pone.0191182Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism.Ying WangZhenzhen LiuYi HanJiping XuWen HuangZhaoshen LiMedium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism. Further investigation demonstrated that the increased mitochondrial biogenesis and metabolism is mediated through the activation of Akt and AMPK signaling pathways and inhibition of TGF-β signaling pathway. Collectively, our findings indicate a beneficial effect of dietary MCT in exercise performance through the increase of mitochondrial biogenesis and metabolism.http://europepmc.org/articles/PMC5805166?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Wang Zhenzhen Liu Yi Han Jiping Xu Wen Huang Zhaoshen Li |
spellingShingle |
Ying Wang Zhenzhen Liu Yi Han Jiping Xu Wen Huang Zhaoshen Li Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. PLoS ONE |
author_facet |
Ying Wang Zhenzhen Liu Yi Han Jiping Xu Wen Huang Zhaoshen Li |
author_sort |
Ying Wang |
title |
Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
title_short |
Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
title_full |
Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
title_fullStr |
Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
title_full_unstemmed |
Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
title_sort |
medium chain triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism. Further investigation demonstrated that the increased mitochondrial biogenesis and metabolism is mediated through the activation of Akt and AMPK signaling pathways and inhibition of TGF-β signaling pathway. Collectively, our findings indicate a beneficial effect of dietary MCT in exercise performance through the increase of mitochondrial biogenesis and metabolism. |
url |
http://europepmc.org/articles/PMC5805166?pdf=render |
work_keys_str_mv |
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