Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems

Tetramethylpyrazine Ameliorates Lipopolysaccharide-Induced Sepsis in Rats via Protecting Blood–Brain Barrier, Impairing Inflammation and Nitrous Oxide Systems

The aim of this study was to assess the underlying impact of Tetramethylpyrazine (TMP), which is the main activity compound of Ligusticum chuanxiong Hort, on the blood–brain barrier, inflammatory and nitrous oxide systems in a rat model of lipopolysaccharide (LPS)-induced sepsis. The SD rats were di...

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Bibliographic Details
Main Authors: Zi-Sheng Huang, Da-Qi Xie, Li-Jun Xu, Chang-Shun Huang, Min Zheng, Yi-Jun Chen, Yin Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
tetramethylpyrazine
lipopolysaccharide
inflammation
blood–brain barrier
nitrous oxide system
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.562084/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.562084/full

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