Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113

CEACAM16 is a non-collagenous protein of the tectorial membrane, an extracellular structure of the cochlea essential for normal hearing. Dominant and recessive mutations in CEACAM16 have been reported to cause postlingual and progressive forms of deafness in humans. In a previous study of young Ceac...

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Bibliographic Details
Main Authors: Richard J. Goodyear, Mary Ann Cheatham, Souvik Naskar, Yingjie Zhou, Richard T. Osgood, Jing Zheng, Guy P. Richardson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlea
hearing
deafness
tectorial membrane
CEACAM16
spontaneous otoacoustic emissions
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00147/full

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