Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study
Background The purpose of this study was to investigate the relationship between chronic periodontitis (CP) and upper urinary tract stone (UUTS) in Taiwan by using a population-based data set. Methods A total of 16,292 CP patients and 48,876 randomly-selected controls without chronic periodontitis w...
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doaj-c15d94b16b6e425484cc36c3f29ef6292020-11-25T01:23:23ZengPeerJ Inc.PeerJ2167-83592018-07-016e528710.7717/peerj.5287Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up studyI-Shen Huang0Sung-En Huang1Wei-Tang Kao2Cheng-Yen Chiang3To Chang4Cheng-I Lin5Alex T. Lin6Chih-Chieh Lin7Yu-Hua Fan8Hsiao-Jen Chung9Department of Physiology, School of Medicine, National Yang-Ming University, Taipei, TaiwanHsinchu City, TaiwanDepartment of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Urology, Surgical Department, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDivision of Urology, Surgical Department, National Yang Ming University Hospital, Yilan, TaiwanHouston, TX, United states of AmericaDepartment of Urology, School of Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Urology, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Urology, School of Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Urology, School of Medicine, National Yang-Ming University, Taipei, TaiwanBackground The purpose of this study was to investigate the relationship between chronic periodontitis (CP) and upper urinary tract stone (UUTS) in Taiwan by using a population-based data set. Methods A total of 16,292 CP patients and 48,876 randomly-selected controls without chronic periodontitis were selected from the National research database and studied retrospectively. Subjects selected have not been diagnosed with UUTS previously. These subjects were prospectively followed for at least eight years. Cox regression models were used to explore the connection between risk factors and the development of UUTS. Results The CP patients have a greater chance of developing UUTS compared to controls (1761/16292, 10.8% vs. 4775/48876, 9.8%, p-values < 0.001). Conditioned logistic regression suggested CP increases the risk of UUTS development (HR 1.14, 95% CI [1.08–1.20], p < 0.001). After respective adjustment for age, gender, hypertension and diabetes, results showed that CP still increases the risk of developing UUTS (HR 1.14, 95% CI [1.08–1.20], p < 0.001). Conclusion By using a population-based database with a minimum eight 8 follow-up of CP in Taiwan, we discovered patients with CP are more likely to develop UUTS.https://peerj.com/articles/5287.pdfChronic periodontitisUrolithiasisUpper urinary tract stone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
I-Shen Huang Sung-En Huang Wei-Tang Kao Cheng-Yen Chiang To Chang Cheng-I Lin Alex T. Lin Chih-Chieh Lin Yu-Hua Fan Hsiao-Jen Chung |
spellingShingle |
I-Shen Huang Sung-En Huang Wei-Tang Kao Cheng-Yen Chiang To Chang Cheng-I Lin Alex T. Lin Chih-Chieh Lin Yu-Hua Fan Hsiao-Jen Chung Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study PeerJ Chronic periodontitis Urolithiasis Upper urinary tract stone |
author_facet |
I-Shen Huang Sung-En Huang Wei-Tang Kao Cheng-Yen Chiang To Chang Cheng-I Lin Alex T. Lin Chih-Chieh Lin Yu-Hua Fan Hsiao-Jen Chung |
author_sort |
I-Shen Huang |
title |
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
title_short |
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
title_full |
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
title_fullStr |
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
title_full_unstemmed |
Patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
title_sort |
patients with chronic periodontitis are more likely to develop upper urinary tract stone: a nation-wide population-based eight-year follow up study |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2018-07-01 |
description |
Background The purpose of this study was to investigate the relationship between chronic periodontitis (CP) and upper urinary tract stone (UUTS) in Taiwan by using a population-based data set. Methods A total of 16,292 CP patients and 48,876 randomly-selected controls without chronic periodontitis were selected from the National research database and studied retrospectively. Subjects selected have not been diagnosed with UUTS previously. These subjects were prospectively followed for at least eight years. Cox regression models were used to explore the connection between risk factors and the development of UUTS. Results The CP patients have a greater chance of developing UUTS compared to controls (1761/16292, 10.8% vs. 4775/48876, 9.8%, p-values < 0.001). Conditioned logistic regression suggested CP increases the risk of UUTS development (HR 1.14, 95% CI [1.08–1.20], p < 0.001). After respective adjustment for age, gender, hypertension and diabetes, results showed that CP still increases the risk of developing UUTS (HR 1.14, 95% CI [1.08–1.20], p < 0.001). Conclusion By using a population-based database with a minimum eight 8 follow-up of CP in Taiwan, we discovered patients with CP are more likely to develop UUTS. |
topic |
Chronic periodontitis Urolithiasis Upper urinary tract stone |
url |
https://peerj.com/articles/5287.pdf |
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