The Application of Ribozymes and DNAzymes in Muscle and Brain
The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ailments. These CNAs aim either towards the elimina...
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2010-08-01
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doaj-c15e3ccbc95d4ca08076a4c64a09ca272020-11-24T21:21:45ZengMDPI AGMolecules1420-30492010-08-011585460547210.3390/molecules15085460The Application of Ribozymes and DNAzymes in Muscle and BrainLeonidas A. PhylactouJames B. UneyNikolaos P. MastroyiannopoulosThe discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ailments. These CNAs aim either towards the elimination or repair of pathological gene expression. Ribozymes, a class of CNAs, can be mostly used to down-regulate (by RNA cleavage) or repair (by RNA trans-splicing) unwanted gene expression involved in disease. DNAzymes, derived by in vitro selection processes are also able to bind and cleave RNA targets and therefore down-regulate gene expression. The purpose of this review is to present and discuss several applications of ribozymes and DNAzymes in muscle and brain. There are several diseases which affect muscle and brain and catalytic nucleic acids have been used as tools to target specific cellular transcripts involved in these groups of diseases. http://www.mdpi.com/1420-3049/15/8/5460/catalytic nucleic acidsribozymeDNAzymebrainmuscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leonidas A. Phylactou James B. Uney Nikolaos P. Mastroyiannopoulos |
spellingShingle |
Leonidas A. Phylactou James B. Uney Nikolaos P. Mastroyiannopoulos The Application of Ribozymes and DNAzymes in Muscle and Brain Molecules catalytic nucleic acids ribozyme DNAzyme brain muscle |
author_facet |
Leonidas A. Phylactou James B. Uney Nikolaos P. Mastroyiannopoulos |
author_sort |
Leonidas A. Phylactou |
title |
The Application of Ribozymes and DNAzymes in Muscle and Brain |
title_short |
The Application of Ribozymes and DNAzymes in Muscle and Brain |
title_full |
The Application of Ribozymes and DNAzymes in Muscle and Brain |
title_fullStr |
The Application of Ribozymes and DNAzymes in Muscle and Brain |
title_full_unstemmed |
The Application of Ribozymes and DNAzymes in Muscle and Brain |
title_sort |
application of ribozymes and dnazymes in muscle and brain |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2010-08-01 |
description |
The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of endogenous gene expression involved in these ailments. These CNAs aim either towards the elimination or repair of pathological gene expression. Ribozymes, a class of CNAs, can be mostly used to down-regulate (by RNA cleavage) or repair (by RNA trans-splicing) unwanted gene expression involved in disease. DNAzymes, derived by in vitro selection processes are also able to bind and cleave RNA targets and therefore down-regulate gene expression. The purpose of this review is to present and discuss several applications of ribozymes and DNAzymes in muscle and brain. There are several diseases which affect muscle and brain and catalytic nucleic acids have been used as tools to target specific cellular transcripts involved in these groups of diseases. |
topic |
catalytic nucleic acids ribozyme DNAzyme brain muscle |
url |
http://www.mdpi.com/1420-3049/15/8/5460/ |
work_keys_str_mv |
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