Alkaloids of the Genus <i>Datura</i>: Review of a Rich Resource for Natural Product Discovery

• Main Authors: Maris A. Cinelli, A. Daniel Jones
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Molecules
• Subjects: alkaloid; Solanaceae; tropane; indole; pyrrolidine; <i>Datura</i>
• Online Access: https://www.mdpi.com/1420-3049/26/9/2629

The genus <i>Datura</i> (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history. This genus’ particular bioactivity results from the enormous diversity of alkaloids it contains, making it a valuable study organism for many disciplines. Although <i>Datura</i> contains mostly tropane alkaloids (such as hyoscyamine and scopolamine), indole, <i>beta</i>-carboline, and pyrrolidine alkaloids have also been identified. The tools available to explore specialized metabolism in plants have undergone remarkable advances over the past couple of decades and provide renewed opportunities for discoveries of new compounds and the genetic basis for their biosynthesis. This review provides a comprehensive overview of studies on the alkaloids of <i>Datura</i> that focuses on three questions: How do we find and identify alkaloids? Where do alkaloids come from? What factors affect their presence and abundance? We also address pitfalls and relevant questions applicable to natural products and metabolomics researchers. With both careful perspectives and new advances in instrumentation, the pace of alkaloid discovery—from not just <i>Datura</i>—has the potential to accelerate dramatically in the near future.