Vaccines for TB: Lessons from the Past Translating into Future Potentials
Development of vaccines for infectious diseases has come a long way with recent advancements in adjuvant developments and discovery of new antigens that are capable of eliciting strong immunological responses for sterile eradication of disease. Tuberculosis (TB) that kills nearly 2 million of the po...
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doaj-c16fdd9af6ac48dfb6f5c74d14ec15f82020-11-24T22:50:46ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/916780916780Vaccines for TB: Lessons from the Past Translating into Future PotentialsGee Jun Tye0Min Han Lew1Yee Siew Choong2Theam Soon Lim3Maria Elena Sarmiento4Armando Acosta5Mohd Nor Norazmi6Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaSchool of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaDevelopment of vaccines for infectious diseases has come a long way with recent advancements in adjuvant developments and discovery of new antigens that are capable of eliciting strong immunological responses for sterile eradication of disease. Tuberculosis (TB) that kills nearly 2 million of the population every year is also one of the highlights of the recent developments. The availability or not of diagnostic methods for infection has implications for the control of the disease by the health systems but is not related to the immune surveillance, a phenomenon derived from the interaction between the bacteria and their host. Here, we will review the immunology of TB and current vaccine candidates for TB. Current strategies of developing new vaccines against TB will also be reviewed in order to further discuss new insights into immunotherapeutic approaches involving adjuvant and antigens combinations that might be of potential for the control of TB.http://dx.doi.org/10.1155/2015/916780 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gee Jun Tye Min Han Lew Yee Siew Choong Theam Soon Lim Maria Elena Sarmiento Armando Acosta Mohd Nor Norazmi |
spellingShingle |
Gee Jun Tye Min Han Lew Yee Siew Choong Theam Soon Lim Maria Elena Sarmiento Armando Acosta Mohd Nor Norazmi Vaccines for TB: Lessons from the Past Translating into Future Potentials Journal of Immunology Research |
author_facet |
Gee Jun Tye Min Han Lew Yee Siew Choong Theam Soon Lim Maria Elena Sarmiento Armando Acosta Mohd Nor Norazmi |
author_sort |
Gee Jun Tye |
title |
Vaccines for TB: Lessons from the Past Translating into Future Potentials |
title_short |
Vaccines for TB: Lessons from the Past Translating into Future Potentials |
title_full |
Vaccines for TB: Lessons from the Past Translating into Future Potentials |
title_fullStr |
Vaccines for TB: Lessons from the Past Translating into Future Potentials |
title_full_unstemmed |
Vaccines for TB: Lessons from the Past Translating into Future Potentials |
title_sort |
vaccines for tb: lessons from the past translating into future potentials |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2015-01-01 |
description |
Development of vaccines for infectious diseases has come a long way with recent advancements in adjuvant developments and discovery of new antigens that are capable of eliciting strong immunological responses for sterile eradication of disease. Tuberculosis (TB) that kills nearly 2 million of the population every year is also one of the highlights of the recent developments. The availability or not of diagnostic methods for infection has implications for the control of the disease by the health systems but is not related to the immune surveillance, a phenomenon derived from the interaction between the bacteria and their host. Here, we will review the immunology of TB and current vaccine candidates for TB. Current strategies of developing new vaccines against TB will also be reviewed in order to further discuss new insights into immunotherapeutic approaches involving adjuvant and antigens combinations that might be of potential for the control of TB. |
url |
http://dx.doi.org/10.1155/2015/916780 |
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