No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.

No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.

Antigen presentation by MHC class I molecules requires degradation of epitope source proteins in the cytosol. Although the preeminent role of the proteasome is clearly established, evidence suggesting a significant role for proteasome-independent generation of class I ligands has been reported repea...

Full description

Bibliographic Details
Main Authors: Slobodan Culina, François-Xavier Mauvais, Hsiang-Ting Hsu, Anne Burgevin, Suzanne Guénette, Anna Moser, Peter van Endert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24516642/?tool=EBI

Similar Items

Similar Items