Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer
Abstract Background Though it is well established that black men are at higher risk of prostate cancer (PCa) very little is known about the disease in native sub Saharan black men. Newly diagnosed metastatic PCa patients treated with primary androgen deprivation therapy were identified and predictor...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-05-01
|
Series: | BMC Urology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12894-017-0228-0 |
id |
doaj-c1889e4977cd4cfa8865d40184aade0d |
---|---|
record_format |
Article |
spelling |
doaj-c1889e4977cd4cfa8865d40184aade0d2020-11-24T21:55:34ZengBMCBMC Urology1471-24902017-05-011711510.1186/s12894-017-0228-0Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancerJibril Oyekunle Bello0Department of Surgery, University of Ilorin Teaching HospitalAbstract Background Though it is well established that black men are at higher risk of prostate cancer (PCa) very little is known about the disease in native sub Saharan black men. Newly diagnosed metastatic PCa patients treated with primary androgen deprivation therapy were identified and predictors of progression-free survival (PFS) assessed. Methods Patients diagnosed with metastatic PCa between 2010 and 2015 in a sub Saharan black population were included in the study. Primary outcome measure was PFS defined as time from primary androgen deprivation therapy to clinical progression or death. Demographic, clinical and PSA kinetic variables were evaluated for their prognostic power using Cox proportional hazard regression models. Results Seventy-nine patients met the eligibility criteria and were analyzed. Median age, median overall survival and PFS was 69 years, 40 months and 27 months respectively. A PSA nadir >4 ng/mL was found to predict an earlier clinical progression. Median PFS was shorter in those with PSA nadir >4 ng/mL (15 months) compared to those with PSA nadir ≤4 ng/mL (29 months); log rank p value = 0.003. Conclusions The PSA nadir achieved following primary androgen deprivation therapy predicts progression-free survival in sub Saharan black men newly diagnosed with metastatic PCa. PSA nadir >4 ng/mL was found to be associated with a more rapid clinical progression.http://link.springer.com/article/10.1186/s12894-017-0228-0Prostate cancerAndrogen deprivation therapyPSA kineticsPSA nadirBlack menSub Saharan Africa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jibril Oyekunle Bello |
spellingShingle |
Jibril Oyekunle Bello Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer BMC Urology Prostate cancer Androgen deprivation therapy PSA kinetics PSA nadir Black men Sub Saharan Africa |
author_facet |
Jibril Oyekunle Bello |
author_sort |
Jibril Oyekunle Bello |
title |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer |
title_short |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer |
title_full |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer |
title_fullStr |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer |
title_full_unstemmed |
Predictors of survival outcomes in native sub Saharan black men newly diagnosed with metastatic prostate cancer |
title_sort |
predictors of survival outcomes in native sub saharan black men newly diagnosed with metastatic prostate cancer |
publisher |
BMC |
series |
BMC Urology |
issn |
1471-2490 |
publishDate |
2017-05-01 |
description |
Abstract Background Though it is well established that black men are at higher risk of prostate cancer (PCa) very little is known about the disease in native sub Saharan black men. Newly diagnosed metastatic PCa patients treated with primary androgen deprivation therapy were identified and predictors of progression-free survival (PFS) assessed. Methods Patients diagnosed with metastatic PCa between 2010 and 2015 in a sub Saharan black population were included in the study. Primary outcome measure was PFS defined as time from primary androgen deprivation therapy to clinical progression or death. Demographic, clinical and PSA kinetic variables were evaluated for their prognostic power using Cox proportional hazard regression models. Results Seventy-nine patients met the eligibility criteria and were analyzed. Median age, median overall survival and PFS was 69 years, 40 months and 27 months respectively. A PSA nadir >4 ng/mL was found to predict an earlier clinical progression. Median PFS was shorter in those with PSA nadir >4 ng/mL (15 months) compared to those with PSA nadir ≤4 ng/mL (29 months); log rank p value = 0.003. Conclusions The PSA nadir achieved following primary androgen deprivation therapy predicts progression-free survival in sub Saharan black men newly diagnosed with metastatic PCa. PSA nadir >4 ng/mL was found to be associated with a more rapid clinical progression. |
topic |
Prostate cancer Androgen deprivation therapy PSA kinetics PSA nadir Black men Sub Saharan Africa |
url |
http://link.springer.com/article/10.1186/s12894-017-0228-0 |
work_keys_str_mv |
AT jibriloyekunlebello predictorsofsurvivaloutcomesinnativesubsaharanblackmennewlydiagnosedwithmetastaticprostatecancer |
_version_ |
1725861841624629248 |