Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the pr...

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Main Authors:	Jyh-Horng Sheu, Yan-Ning Lee, Chi-Jen Tai, Tsong-Long Hwang
Format:	Article
Language:	English
Published:	MDPI AG 2013-08-01
Series:	Marine Drugs
Subjects:	Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent
Online Access:	http://www.mdpi.com/1660-3397/11/8/2741

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spelling	doaj-c18b8fd9123d48d6a8be609a08bbe46b2020-11-24T21:25:03ZengMDPI AGMarine Drugs1660-33972013-08-011182741275010.3390/md11082741Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfiJyh-Horng SheuYan-Ning LeeChi-Jen TaiTsong-Long HwangNew four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.http://www.mdpi.com/1660-3397/11/8/2741Cladiella krempfieunicellin-based diterpenoidelastaseanti-inflammatory agent
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jyh-Horng Sheu Yan-Ning Lee Chi-Jen Tai Tsong-Long Hwang
spellingShingle	Jyh-Horng Sheu Yan-Ning Lee Chi-Jen Tai Tsong-Long Hwang Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi Marine Drugs Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent
author_facet	Jyh-Horng Sheu Yan-Ning Lee Chi-Jen Tai Tsong-Long Hwang
author_sort	Jyh-Horng Sheu
title	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_short	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_full	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_fullStr	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_full_unstemmed	Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_sort	krempfielins j-m, new eunicellin-based diterpenoids from the soft coral cladiella krempfi
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2013-08-01
description	New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
topic	Cladiella krempfi eunicellin-based diterpenoid elastase anti-inflammatory agent
url	http://www.mdpi.com/1660-3397/11/8/2741
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Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

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