Goodpasture’s syndrome in 17-year-old patient

• Main Authors: D Yu Ovsyannikov, M Yu Volkov, A A Glazyrina, Ya V Marchenkov, Sh A Gitinov, P S Rogatkin, I Ye Koltunov
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2016-12-01
• Series: RUDN Journal of Medicine
• Subjects: синдром Гудпасчера; легочно-почечный синдром; антитела к базальной мембране клубочков; криоглобулины; дети
• Online Access: http://journals.rudn.ru/medicine/article/view/3756

Goodpasture’s syndrome (GS) is a severe autoimmune disease, which is characterized by kidney and lung affection. Antibodies to glomerular basal membrane (AGBM) are considered to be a specific marker. We present a literature review and a clinical case of GS with typical clinical presentation and low effectiveness of glucocorticosteroid treatment in 17-year-old patient. The disease was characterized by the AGBM disappearance from peripheral blood, positive test for cryoglobulins and improvement of patient condition during therapy with rituximab.