Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy

Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy

This study was conducted to elucidate the involvement of the PINK1-Parkin pathway in ethanol-induced mitophagy among Sertoli cells (SCs). In the research, adult rats were given intraperitoneal injections of ethanol (5 gm/kg) and sacrificed at various time periods within 24 h. Transmission electron m...

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Bibliographic Details
Main Authors: Nabil Eid, Yuko Ito, Akio Horibe, Yoshinori Otsuki, Yoichi Kondo
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
ethanol
mitochondria
autophagy
LC3
apoptosis
Sertoli cell
Parkin
PINK1
TFEB
mitophagy
infertility
Online Access:https://www.mdpi.com/2073-4409/8/3/283

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