Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope?
BackgroundHead and neck squamous cell carcinoma (HNSCC) carries poor survival outcomes despite recent progress in cancer treatment in general. Angiogenesis is crucial for tumour survival and progression. Therefore, several agents targeting the pathways that mediate angiogenesis have been developed....
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doaj-c1971bb293a9400683e8975ca00ce5882021-06-14T09:03:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.683570683570Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope?Aini Hyytiäinen0Aini Hyytiäinen1Wafa Wahbi2Wafa Wahbi3Otto Väyrynen4Kauko Saarilahti5Peeter Karihtala6Tuula Salo7Tuula Salo8Tuula Salo9Tuula Salo10Tuula Salo11Ahmed Al-Samadi12Ahmed Al-Samadi13Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, FinlandTranslational Immunology Programme, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, FinlandTranslational Immunology Programme, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, FinlandDepartment of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandDepartment of Oncology, Helsinki University Hospital Comprehensive Cancer Centre and University of Helsinki, Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, FinlandTranslational Immunology Programme, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Pathology, University of Helsinki, Helsinki, FinlandCancer Research and Translational Medicine Research Unit, University of Oulu, Oulu, FinlandOulu Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, FinlandTranslational Immunology Programme, Faculty of Medicine, University of Helsinki, Helsinki, FinlandBackgroundHead and neck squamous cell carcinoma (HNSCC) carries poor survival outcomes despite recent progress in cancer treatment in general. Angiogenesis is crucial for tumour survival and progression. Therefore, several agents targeting the pathways that mediate angiogenesis have been developed. We conducted a systematic review to summarise the current clinical trial data examining angiogenesis inhibitors in HNSCC.MethodsWe carried out a literature search on three angiogenesis inhibitor categories—bevacizumab, tyrosine kinase inhibitors and endostatin—from Ovid MEDLINE, Cochrane Library, Scopus and ClinicalTrials.gov database.ResultsHere, we analysed 38 clinical trials, total of 1670 patients, investigating 12 angiogenesis inhibitors. All trials were in phase I or II, except one study in phase III on bevacizumab. Angiogenesis inhibitors were used as mono- and combination therapies together with radio-, chemo-, targeted- or immunotherapy. Among 12 angiogenesis inhibitors, bevacizumab was the most studied drug, included in 13 trials. Although bevacizumab appeared effective in various combinations, it associated with high toxicity levels. Endostatin and lenvatinib were well-tolerated and their anticancer effects appeared promising.ConclusionsMost studies did not show benefit of angiogenesis inhibitors in HNSCC treatment. Additionally, angiogenesis inhibitors were associated with considerable toxicity. However, some results appear encouraging, suggesting that further investigations of angiogenesis inhibitors, particularly in combination therapies, for HNSCC patients are warranted.Systematic Review RegistrationPROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42020157144.https://www.frontiersin.org/articles/10.3389/fonc.2021.683570/fullanti-angiogenesishead and neck cancertherapyendostatinbevacizumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aini Hyytiäinen Aini Hyytiäinen Wafa Wahbi Wafa Wahbi Otto Väyrynen Kauko Saarilahti Peeter Karihtala Tuula Salo Tuula Salo Tuula Salo Tuula Salo Tuula Salo Ahmed Al-Samadi Ahmed Al-Samadi |
spellingShingle |
Aini Hyytiäinen Aini Hyytiäinen Wafa Wahbi Wafa Wahbi Otto Väyrynen Kauko Saarilahti Peeter Karihtala Tuula Salo Tuula Salo Tuula Salo Tuula Salo Tuula Salo Ahmed Al-Samadi Ahmed Al-Samadi Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? Frontiers in Oncology anti-angiogenesis head and neck cancer therapy endostatin bevacizumab |
author_facet |
Aini Hyytiäinen Aini Hyytiäinen Wafa Wahbi Wafa Wahbi Otto Väyrynen Kauko Saarilahti Peeter Karihtala Tuula Salo Tuula Salo Tuula Salo Tuula Salo Tuula Salo Ahmed Al-Samadi Ahmed Al-Samadi |
author_sort |
Aini Hyytiäinen |
title |
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? |
title_short |
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? |
title_full |
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? |
title_fullStr |
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? |
title_full_unstemmed |
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope? |
title_sort |
angiogenesis inhibitors for head and neck squamous cell carcinoma treatment: is there still hope? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-06-01 |
description |
BackgroundHead and neck squamous cell carcinoma (HNSCC) carries poor survival outcomes despite recent progress in cancer treatment in general. Angiogenesis is crucial for tumour survival and progression. Therefore, several agents targeting the pathways that mediate angiogenesis have been developed. We conducted a systematic review to summarise the current clinical trial data examining angiogenesis inhibitors in HNSCC.MethodsWe carried out a literature search on three angiogenesis inhibitor categories—bevacizumab, tyrosine kinase inhibitors and endostatin—from Ovid MEDLINE, Cochrane Library, Scopus and ClinicalTrials.gov database.ResultsHere, we analysed 38 clinical trials, total of 1670 patients, investigating 12 angiogenesis inhibitors. All trials were in phase I or II, except one study in phase III on bevacizumab. Angiogenesis inhibitors were used as mono- and combination therapies together with radio-, chemo-, targeted- or immunotherapy. Among 12 angiogenesis inhibitors, bevacizumab was the most studied drug, included in 13 trials. Although bevacizumab appeared effective in various combinations, it associated with high toxicity levels. Endostatin and lenvatinib were well-tolerated and their anticancer effects appeared promising.ConclusionsMost studies did not show benefit of angiogenesis inhibitors in HNSCC treatment. Additionally, angiogenesis inhibitors were associated with considerable toxicity. However, some results appear encouraging, suggesting that further investigations of angiogenesis inhibitors, particularly in combination therapies, for HNSCC patients are warranted.Systematic Review RegistrationPROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42020157144. |
topic |
anti-angiogenesis head and neck cancer therapy endostatin bevacizumab |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.683570/full |
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