Respiratory Syncytial Virus: Current Progress in Vaccine Development
Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the findi...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-02-01
|
Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/5/2/577 |
id |
doaj-c1ac74d207674357bc9b5b1b2353e606 |
---|---|
record_format |
Article |
spelling |
doaj-c1ac74d207674357bc9b5b1b2353e6062020-11-24T23:25:33ZengMDPI AGViruses1999-49152013-02-015257759410.3390/v5020577Respiratory Syncytial Virus: Current Progress in Vaccine DevelopmentJulia L. HurwitzSherri L. SurmanRajeev RudrarajuRobert SealyBart G. JonesRespiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infection risks are inversely associated with neutralizing antibody titers suggest that immune responses generated toward a first RSV exposure can significantly reduce morbidity and mortality throughout life. For more than half a century, researchers have endeavored to design a vaccine for RSV that can mimic or improve upon natural protective immunity without adverse events. The virus is herein described together with the hurdles that must be overcome to develop a vaccine and some current vaccine development approaches.http://www.mdpi.com/1999-4915/5/2/577respiratory syncytial viruscandidate vaccinesprotective immunity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julia L. Hurwitz Sherri L. Surman Rajeev Rudraraju Robert Sealy Bart G. Jones |
spellingShingle |
Julia L. Hurwitz Sherri L. Surman Rajeev Rudraraju Robert Sealy Bart G. Jones Respiratory Syncytial Virus: Current Progress in Vaccine Development Viruses respiratory syncytial virus candidate vaccines protective immunity |
author_facet |
Julia L. Hurwitz Sherri L. Surman Rajeev Rudraraju Robert Sealy Bart G. Jones |
author_sort |
Julia L. Hurwitz |
title |
Respiratory Syncytial Virus: Current Progress in Vaccine Development |
title_short |
Respiratory Syncytial Virus: Current Progress in Vaccine Development |
title_full |
Respiratory Syncytial Virus: Current Progress in Vaccine Development |
title_fullStr |
Respiratory Syncytial Virus: Current Progress in Vaccine Development |
title_full_unstemmed |
Respiratory Syncytial Virus: Current Progress in Vaccine Development |
title_sort |
respiratory syncytial virus: current progress in vaccine development |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2013-02-01 |
description |
Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infection risks are inversely associated with neutralizing antibody titers suggest that immune responses generated toward a first RSV exposure can significantly reduce morbidity and mortality throughout life. For more than half a century, researchers have endeavored to design a vaccine for RSV that can mimic or improve upon natural protective immunity without adverse events. The virus is herein described together with the hurdles that must be overcome to develop a vaccine and some current vaccine development approaches. |
topic |
respiratory syncytial virus candidate vaccines protective immunity |
url |
http://www.mdpi.com/1999-4915/5/2/577 |
work_keys_str_mv |
AT julialhurwitz respiratorysyncytialviruscurrentprogressinvaccinedevelopment AT sherrilsurman respiratorysyncytialviruscurrentprogressinvaccinedevelopment AT rajeevrudraraju respiratorysyncytialviruscurrentprogressinvaccinedevelopment AT robertsealy respiratorysyncytialviruscurrentprogressinvaccinedevelopment AT bartgjones respiratorysyncytialviruscurrentprogressinvaccinedevelopment |
_version_ |
1725556949417721856 |