The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.

The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.

Overcoming spaceflight-induced (patho)physiologic adaptations is a major challenge preventing long-term deep space exploration. RNA interference (RNAi) has emerged as a promising therapeutic for combating diseases on Earth; however the efficacy of RNAi in space is currently unknown.Caenorhabditis el...

Full description

Bibliographic Details
Main Authors:	Timothy Etheridge, Kanako Nemoto, Toko Hashizume, Chihiro Mori, Tomoko Sugimoto, Hiromi Suzuki, Keiji Fukui, Takashi Yamazaki, Akira Higashibata, Nathaniel J Szewczyk, Atsushi Higashitani
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3105993?pdf=render

Similar Items

Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans
by: Ricardo Laranjeiro, et al.
Published: (2021-02-01)

Natural and unanticipated modifiers of RNAi activity in Caenorhabditis elegans.
by: Nadeem Asad, et al.
Published: (2012-01-01)

Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans
by: Zhao, Yani
Published: (2017)

Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans
by: Holmgren, Benjamin T.
Published: (2017)

Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans
by: Atsushi Higashitani, et al.
Published: (2021-09-01)

New Strains for Tissue-Specific RNAi Studies in Caenorhabditis elegans
by: Jason S. Watts, et al.
Published: (2020-11-01)

Chemically defined medium and <it>Caenorhabditis elegans</it>
by: Kozak Elena, et al.
Published: (2003-10-01)

Visualization and Quantification of Transposon Activity in Caenorhabditis elegans RNAi Pathway Mutants
by: Dylan C. Wallis, et al.
Published: (2019-11-01)

Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.
by: Timothy Etheridge, et al.
Published: (2012-01-01)

RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line
by: Megan P. Wood, et al.
Published: (2016-08-01)

A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans.
by: Richard J Poole, et al.
Published: (2011-06-01)

Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans
by: Craig R.G. Willis, et al.
Published: (2020-12-01)

The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans.
by: Katlin B Massirer, et al.
Published: (2012-01-01)

A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.
by: Andres R Mansisidor, et al.
Published: (2011-09-01)

A Conserved PHD Finger Protein and Endogenous RNAi Modulate Insulin Signaling in Caenorhabditis elegans
by: Mansisidor, Andres R., et al.
Published: (2012)

<i>Caenorhabditis elegans</i> as a Model System for Duchenne Muscular Dystrophy
by: Rebecca A. Ellwood, et al.
Published: (2021-05-01)

A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2.
by: Mark G Sterken, et al.
Published: (2014-01-01)

Reliability analysis of the Ahringer <it>Caenorhabditis elegans </it>RNAi feeding library: a guide for genome-wide screens
by: Lu Yiming, et al.
Published: (2011-03-01)

Whole-genome analysis of 60 G protein-coupled receptors in Caenorhabditis elegans by gene knockout with RNAi
by: Keating, C.D, et al.
Published: (2003)

A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.
by: Matthew D Nelson, et al.
Published: (2011-03-01)

ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.
by: Karolina M Andralojc, et al.
Published: (2017-02-01)

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs
by: Jennifer E. Hewitt, et al.
Published: (2018-12-01)

New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.
by: Malene Hansen, et al.
Published: (2005-07-01)

An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans.
by: Rui Lu, et al.
Published: (2009-02-01)

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen.
Published: (2005-07-01)

The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
by: Christina Fassnacht, et al.
Published: (2018-03-01)

RNAi STUDIES IN CAENORHABDITIS ELEGANS REVEAL THAT COENZYME Q PROTECTS GABA NEURONS FROM APOPTOTIC, CALCIUM-DEPENDENT DEGENERATION
by: Earls, Laurie Rebecca
Published: (2007)

Microarray analysis of ncRNA expression patterns in <it>Caenorhabditis elegans </it>after RNAi against snoRNA associated proteins
by: Skogerbø Geir, et al.
Published: (2008-06-01)

The identification of new regulators of phase II detoxification gene expression by a genome-wide RNAi screen in Caenorhabditis elegans
by: Crook, Helen Marie
Published: (2011)

Immunometabolism in Caenorhabditis elegans.
by: Sarah M Anderson, et al.
Published: (2020-10-01)

The Nucleolus of Caenorhabditis elegans
by: Li-Wei Lee, et al.
Published: (2012-01-01)

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans
by: Richard Venz, et al.
Published: (2020-11-01)

A pre- and co-knockdown of RNAseT enzyme, Eri-1, enhances the efficiency of RNAi induced gene silencing in Caenorhabditis elegans.
by: Pooja Jadiya, et al.
Published: (2014-01-01)

Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3
by: Lianna Schwartz-Orbach, et al.
Published: (2020-08-01)

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.
by: Eleonora Khabirova, et al.
Published: (2014-01-01)

A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target.
by: Taixiang Saur, et al.
Published: (2013-01-01)

The Biosynthesis of Ascarosides in Caenorhabditis elegans
by: Akagi, Allison Emi
Published: (2018)

Foraging behavior of Caenorhabditis elegans
by: Mao-Ting Cheng, et al.
Published: (2017)

Transcriptional adaptation in Caenorhabditis elegans
by: Vahan Serobyan, et al.
Published: (2020-01-01)

Untwisting the Caenorhabditis elegans embryo
by: Ryan Patrick Christensen, et al.
Published: (2015-12-01)

Cannot write session to /tmp/vufind_sessions/sess_d6uvm3euharl4a7sda746m2mbl