Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats
The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2011-01-01
|
Series: | Journal of Thyroid Research |
Online Access: | http://dx.doi.org/10.4061/2011/214924 |
id |
doaj-c1bbe01b4d0c425badb55e8c317ab97b |
---|---|
record_format |
Article |
spelling |
doaj-c1bbe01b4d0c425badb55e8c317ab97b2020-11-24T23:19:35ZengHindawi LimitedJournal of Thyroid Research2042-00722011-01-01201110.4061/2011/214924214924Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar RatsSuleiman F. Ambali0Chinedu Orieji1Woziri O. Abubakar2Muftau Shittu3Mohammed U. Kawu4Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, NigeriaDepartment of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, NigeriaDepartment of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, NigeriaDepartment of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, NigeriaDepartment of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, NigeriaThe present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively. Group III was coadministered CPF (4.25 mg/kg ~1/20th LD50) and Pb (250 mg/kg ~1/20th LD50), respectively. Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later. The regimens were administered by gavage for a period of 9 weeks. The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties.http://dx.doi.org/10.4061/2011/214924 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suleiman F. Ambali Chinedu Orieji Woziri O. Abubakar Muftau Shittu Mohammed U. Kawu |
spellingShingle |
Suleiman F. Ambali Chinedu Orieji Woziri O. Abubakar Muftau Shittu Mohammed U. Kawu Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats Journal of Thyroid Research |
author_facet |
Suleiman F. Ambali Chinedu Orieji Woziri O. Abubakar Muftau Shittu Mohammed U. Kawu |
author_sort |
Suleiman F. Ambali |
title |
Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats |
title_short |
Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats |
title_full |
Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats |
title_fullStr |
Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats |
title_full_unstemmed |
Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats |
title_sort |
ameliorative effect of vitamin c on alterations in thyroid hormones concentrations induced by subchronic coadministration of chlorpyrifos and lead in wistar rats |
publisher |
Hindawi Limited |
series |
Journal of Thyroid Research |
issn |
2042-0072 |
publishDate |
2011-01-01 |
description |
The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively. Group III was coadministered CPF (4.25 mg/kg ~1/20th LD50) and Pb (250 mg/kg ~1/20th LD50), respectively. Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later. The regimens were administered by gavage for a period of 9 weeks. The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties. |
url |
http://dx.doi.org/10.4061/2011/214924 |
work_keys_str_mv |
AT suleimanfambali ameliorativeeffectofvitaminconalterationsinthyroidhormonesconcentrationsinducedbysubchroniccoadministrationofchlorpyrifosandleadinwistarrats AT chineduorieji ameliorativeeffectofvitaminconalterationsinthyroidhormonesconcentrationsinducedbysubchroniccoadministrationofchlorpyrifosandleadinwistarrats AT wozirioabubakar ameliorativeeffectofvitaminconalterationsinthyroidhormonesconcentrationsinducedbysubchroniccoadministrationofchlorpyrifosandleadinwistarrats AT muftaushittu ameliorativeeffectofvitaminconalterationsinthyroidhormonesconcentrationsinducedbysubchroniccoadministrationofchlorpyrifosandleadinwistarrats AT mohammedukawu ameliorativeeffectofvitaminconalterationsinthyroidhormonesconcentrationsinducedbysubchroniccoadministrationofchlorpyrifosandleadinwistarrats |
_version_ |
1725578150739443712 |