Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility

The incorporation of well-dispersed graphene (G) powder to polymethyl methacrylate (PMMA) bone cement has been demonstrated as a promising solution to improving its mechanical performance. However, two crucial aspects limit the effectiveness of G as a reinforcing agent: (1) the poor dispersion and (...

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Main Authors: Eva Paz, Yolanda Ballesteros, Juana Abenojar, Nicholas Dunne, Juan C. del Real
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Nanomaterials
Subjects:
Online Access:https://www.mdpi.com/2079-4991/11/1/139
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spelling doaj-c1c3fff0997a4166a5db50a44606c1382021-01-09T00:06:09ZengMDPI AGNanomaterials2079-49912021-01-011113913910.3390/nano11010139Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and BiocompatibilityEva Paz0Yolanda Ballesteros1Juana Abenojar2Nicholas Dunne3Juan C. del Real4Institute for Research in Technology, ICAI, Comillas Pontifical University, Santa Cruz de Marcenado, 26, 28015 Madrid, SpainInstitute for Research in Technology, ICAI, Comillas Pontifical University, Santa Cruz de Marcenado, 26, 28015 Madrid, SpainIn-Service Material Performance Group, Materials Science and Engineering and Chemical Engineering Department, “Álvaro Alonso Barba” Institute of Chemistry and Materials Technology, Universidad Carlos III de Madrid. Av. Universidad, 30, 28911 Leganés, SpainCentre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Stokes Building, Collins Avenue, D09 E432 Dublin 9, IrelandInstitute for Research in Technology, ICAI, Comillas Pontifical University, Santa Cruz de Marcenado, 26, 28015 Madrid, SpainThe incorporation of well-dispersed graphene (G) powder to polymethyl methacrylate (PMMA) bone cement has been demonstrated as a promising solution to improving its mechanical performance. However, two crucial aspects limit the effectiveness of G as a reinforcing agent: (1) the poor dispersion and (2) the lack of strong interfacial bonds between G and the matrix of the bone cement. This work reports a successful functionalisation route to promote the homogenous dispersion of G via silanisation using 3-methacryloxypropyltrimethoxy silane (MPS). Furthermore, the effects of the silanisation on the mechanical, thermal and biocompatibility properties of bone cements are presented. In comparison with unsilanised G, the incorporation of silanised G (G_MPS1 and G_MPS2) increased the bending strength by 17%, bending modulus by 15% and deflection at failure by 17%. The most impressive results were obtained for the mechanical properties under fatigue loading, where the incorporation of G_MPS doubled the Fatigue Performance Index (I) value of unsilanised G-bone cement—meaning a 900% increase over the I value of the cement without G. Additionally, to ensure that the silanisation did not have a negative influence on other fundamental properties of bone cement, it was demonstrated that the thermal properties and biocompatibility were not negatively impacted—allowing its potential clinical progression.https://www.mdpi.com/2079-4991/11/1/139graphenesilanebone cementfatiguebiocompatibilitysilanisation
collection DOAJ
language English
format Article
sources DOAJ
author Eva Paz
Yolanda Ballesteros
Juana Abenojar
Nicholas Dunne
Juan C. del Real
spellingShingle Eva Paz
Yolanda Ballesteros
Juana Abenojar
Nicholas Dunne
Juan C. del Real
Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
Nanomaterials
graphene
silane
bone cement
fatigue
biocompatibility
silanisation
author_facet Eva Paz
Yolanda Ballesteros
Juana Abenojar
Nicholas Dunne
Juan C. del Real
author_sort Eva Paz
title Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
title_short Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
title_full Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
title_fullStr Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
title_full_unstemmed Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility
title_sort advanced g-mps-pmma bone cements: influence of graphene silanisation on fatigue performance, thermal properties and biocompatibility
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2021-01-01
description The incorporation of well-dispersed graphene (G) powder to polymethyl methacrylate (PMMA) bone cement has been demonstrated as a promising solution to improving its mechanical performance. However, two crucial aspects limit the effectiveness of G as a reinforcing agent: (1) the poor dispersion and (2) the lack of strong interfacial bonds between G and the matrix of the bone cement. This work reports a successful functionalisation route to promote the homogenous dispersion of G via silanisation using 3-methacryloxypropyltrimethoxy silane (MPS). Furthermore, the effects of the silanisation on the mechanical, thermal and biocompatibility properties of bone cements are presented. In comparison with unsilanised G, the incorporation of silanised G (G_MPS1 and G_MPS2) increased the bending strength by 17%, bending modulus by 15% and deflection at failure by 17%. The most impressive results were obtained for the mechanical properties under fatigue loading, where the incorporation of G_MPS doubled the Fatigue Performance Index (I) value of unsilanised G-bone cement—meaning a 900% increase over the I value of the cement without G. Additionally, to ensure that the silanisation did not have a negative influence on other fundamental properties of bone cement, it was demonstrated that the thermal properties and biocompatibility were not negatively impacted—allowing its potential clinical progression.
topic graphene
silane
bone cement
fatigue
biocompatibility
silanisation
url https://www.mdpi.com/2079-4991/11/1/139
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