Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684...
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doaj-c1c4f720502440caa4db52ae9eabb9ea2020-11-25T02:19:00ZengElsevierEBioMedicine2352-39642015-10-012101549155810.1016/j.ebiom.2015.07.029Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenariansYasumichi Arai0Carmen M. Martin-Ruiz1Michiyo Takayama2Yukiko Abe3Toru Takebayashi4Shigeo Koyasu5Makoto Suematsu6Nobuyoshi Hirose7Thomas von Zglinicki8Centre for Supercentenarian Research, Keio University School of Medicine, Tokyo, JapanNewcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, UKCentre for Preventive Medicine, Keio University School of Medicine, Tokyo, JapanCentre for Supercentenarian Research, Keio University School of Medicine, Tokyo, JapanDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, JapanLaboratory for Immune Cell Systems, RIKEN Centre for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, JapanCentre for Supercentenarian Research, Keio University School of Medicine, Tokyo, JapanCentre for Supercentenarian Research, Keio University School of Medicine, Tokyo, JapanNewcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, UKTo determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99 years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains. In Cox proportional hazard models, inflammation predicted all-cause mortality with hazard ratios (95% CI) 1.89 (1.21 to 2.95) and 1.36 (1.05 to 1.78) in the very old and (semi-)supercentenarians, respectively. In linear forward stepwise models, inflammation predicted capability (10.8% variance explained) and cognition (8.6% variance explained) in (semi-)supercentenarians better than chronologic age or gender. The inflammation score was also lower in centenarian offspring compared to age-matched controls with Δ (95% CI) = −0.795 (−1.436 to −0.154). Centenarians and their offspring were able to maintain long telomeres, but telomere length was not a predictor of successful ageing in centenarians and semi-supercentenarians. We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans.http://www.sciencedirect.com/science/article/pii/S2352396415300815CentenarianAgeingInflammationTelomere |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yasumichi Arai Carmen M. Martin-Ruiz Michiyo Takayama Yukiko Abe Toru Takebayashi Shigeo Koyasu Makoto Suematsu Nobuyoshi Hirose Thomas von Zglinicki |
spellingShingle |
Yasumichi Arai Carmen M. Martin-Ruiz Michiyo Takayama Yukiko Abe Toru Takebayashi Shigeo Koyasu Makoto Suematsu Nobuyoshi Hirose Thomas von Zglinicki Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians EBioMedicine Centenarian Ageing Inflammation Telomere |
author_facet |
Yasumichi Arai Carmen M. Martin-Ruiz Michiyo Takayama Yukiko Abe Toru Takebayashi Shigeo Koyasu Makoto Suematsu Nobuyoshi Hirose Thomas von Zglinicki |
author_sort |
Yasumichi Arai |
title |
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians |
title_short |
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians |
title_full |
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians |
title_fullStr |
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians |
title_full_unstemmed |
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians |
title_sort |
inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2015-10-01 |
description |
To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99 years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains. In Cox proportional hazard models, inflammation predicted all-cause mortality with hazard ratios (95% CI) 1.89 (1.21 to 2.95) and 1.36 (1.05 to 1.78) in the very old and (semi-)supercentenarians, respectively. In linear forward stepwise models, inflammation predicted capability (10.8% variance explained) and cognition (8.6% variance explained) in (semi-)supercentenarians better than chronologic age or gender. The inflammation score was also lower in centenarian offspring compared to age-matched controls with Δ (95% CI) = −0.795 (−1.436 to −0.154). Centenarians and their offspring were able to maintain long telomeres, but telomere length was not a predictor of successful ageing in centenarians and semi-supercentenarians. We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans. |
topic |
Centenarian Ageing Inflammation Telomere |
url |
http://www.sciencedirect.com/science/article/pii/S2352396415300815 |
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