Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy
Background: Irinotecan is commonly used in combination with oxaliplatin as a component of FOLFIRINOX chemotherapy for several gastrointestinal malignancies. The purpose of this case report is to describe a patient who developed acute paralysis and aphasia while receiving her initial infusion of irin...
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doaj-c1cae7d21c0d4a4fa7ca9e96d3bacaa52020-11-24T22:57:01ZengKarger PublishersCase Reports in Oncology1662-65752015-03-018113814110.1159/000380849380849Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX ChemotherapyManisha ChandarRobert de Wilton MarshBackground: Irinotecan is commonly used in combination with oxaliplatin as a component of FOLFIRINOX chemotherapy for several gastrointestinal malignancies. The purpose of this case report is to describe a patient who developed acute paralysis and aphasia while receiving her initial infusion of irinotecan. Case Report: A 67-year-old woman with newly diagnosed metastatic pancreatic adenocarcinoma presented for her first cycle of FOLFIRINOX chemotherapy. During her infusion of irinotecan, she developed acute onset of generalized weakness, paralysis of all extremities, and nonfluent aphasia with complete inability to communicate. This episode was self-limited and resolved within 2 h. Prior to subsequent infusions she received intravenous repletion of potassium and had no recurrence of symptoms. Discussion: In selected cases, coadministration of irinotecan and oxaliplatin may result in severe generalized weakness and aphasia, which may be triggered by underlying electrolyte disturbances. Careful monitoring and correction of potassium may help prevent this reaction.http://www.karger.com/Article/FullText/380849WeaknessDysarthriaNeurologic side effectsIrinotecanOxaliplatinFOLFIRINOXParalysisAphasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manisha Chandar Robert de Wilton Marsh |
spellingShingle |
Manisha Chandar Robert de Wilton Marsh Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy Case Reports in Oncology Weakness Dysarthria Neurologic side effects Irinotecan Oxaliplatin FOLFIRINOX Paralysis Aphasia |
author_facet |
Manisha Chandar Robert de Wilton Marsh |
author_sort |
Manisha Chandar |
title |
Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy |
title_short |
Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy |
title_full |
Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy |
title_fullStr |
Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy |
title_full_unstemmed |
Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy |
title_sort |
severe generalized weakness, paralysis, and aphasia following administration of irinotecan and oxaliplatin during folfirinox chemotherapy |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2015-03-01 |
description |
Background: Irinotecan is commonly used in combination with oxaliplatin as a component of FOLFIRINOX chemotherapy for several gastrointestinal malignancies. The purpose of this case report is to describe a patient who developed acute paralysis and aphasia while receiving her initial infusion of irinotecan. Case Report: A 67-year-old woman with newly diagnosed metastatic pancreatic adenocarcinoma presented for her first cycle of FOLFIRINOX chemotherapy. During her infusion of irinotecan, she developed acute onset of generalized weakness, paralysis of all extremities, and nonfluent aphasia with complete inability to communicate. This episode was self-limited and resolved within 2 h. Prior to subsequent infusions she received intravenous repletion of potassium and had no recurrence of symptoms. Discussion: In selected cases, coadministration of irinotecan and oxaliplatin may result in severe generalized weakness and aphasia, which may be triggered by underlying electrolyte disturbances. Careful monitoring and correction of potassium may help prevent this reaction. |
topic |
Weakness Dysarthria Neurologic side effects Irinotecan Oxaliplatin FOLFIRINOX Paralysis Aphasia |
url |
http://www.karger.com/Article/FullText/380849 |
work_keys_str_mv |
AT manishachandar severegeneralizedweaknessparalysisandaphasiafollowingadministrationofirinotecanandoxaliplatinduringfolfirinoxchemotherapy AT robertdewiltonmarsh severegeneralizedweaknessparalysisandaphasiafollowingadministrationofirinotecanandoxaliplatinduringfolfirinoxchemotherapy |
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1725652376101060608 |