MPT64 assays for the rapid detection of Mycobacterium tuberculosis
Abstract Background Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection a...
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doaj-c1cf43cf026b40d7b8738c5619fbf6762021-04-11T11:08:24ZengBMCBMC Infectious Diseases1471-23342021-04-0121111510.1186/s12879-021-06022-wMPT64 assays for the rapid detection of Mycobacterium tuberculosisXun-Jie Cao0Ya-Ping Li1Jia-Ying Wang2Jie Zhou3Xu-Guang Guo4Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical UniversityAbstract Background Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection. Methods We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis. Results Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99. Conclusions MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.https://doi.org/10.1186/s12879-021-06022-wMPT64Mycobacterium tuberculosisTuberculosisMTBCommercial kits |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xun-Jie Cao Ya-Ping Li Jia-Ying Wang Jie Zhou Xu-Guang Guo |
spellingShingle |
Xun-Jie Cao Ya-Ping Li Jia-Ying Wang Jie Zhou Xu-Guang Guo MPT64 assays for the rapid detection of Mycobacterium tuberculosis BMC Infectious Diseases MPT64 Mycobacterium tuberculosis Tuberculosis MTB Commercial kits |
author_facet |
Xun-Jie Cao Ya-Ping Li Jia-Ying Wang Jie Zhou Xu-Guang Guo |
author_sort |
Xun-Jie Cao |
title |
MPT64 assays for the rapid detection of Mycobacterium tuberculosis |
title_short |
MPT64 assays for the rapid detection of Mycobacterium tuberculosis |
title_full |
MPT64 assays for the rapid detection of Mycobacterium tuberculosis |
title_fullStr |
MPT64 assays for the rapid detection of Mycobacterium tuberculosis |
title_full_unstemmed |
MPT64 assays for the rapid detection of Mycobacterium tuberculosis |
title_sort |
mpt64 assays for the rapid detection of mycobacterium tuberculosis |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2021-04-01 |
description |
Abstract Background Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection. Methods We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis. Results Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99. Conclusions MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits. |
topic |
MPT64 Mycobacterium tuberculosis Tuberculosis MTB Commercial kits |
url |
https://doi.org/10.1186/s12879-021-06022-w |
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