Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells

Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells

Abstract Background Breast cancer is the most frequently diagnosed malignancy among women and the second leading cause of cancer death worldwide. Among which nuclear estrogen receptor (nER) negative breast cancer is always with much poor prognosis. Recently, membrane G protein coupled estrogen recep...

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Bibliographic Details
Main Authors: Danning Shi, Piwen Zhao, Lixia Cui, Hongbo Li, Liping Sun, Jianzhao Niu, Meng Chen
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Cryptotanshinone
GPER
Breast cancer
Cell cycle
Cyclin
PI3K/AKT
Online Access:http://link.springer.com/article/10.1186/s40360-020-00410-9

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