Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways

Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways

Inflammation contributes to leukocyte migration, termed insulitis, and β-cell loss in type 1 diabetes (T1D). Naturally occurring anthraquinones are claimed as anti-inflammatory compounds; however, their actions are not clear. This study aimed to investigate the effect and mechanism of catenarin on t...

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Main Authors: Ming-Yi Shen, Yu-Ping Lin, Bei-Chang Yang, Yu-Song Jang, Chih-Kang Chiang, Clément Mettling, Zeng-Weng Chen, Joen-Rong Sheu, Cicero L. Chang, Yea-Lih Lin, Wen-Chin Yang
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2012/982396

Internet

http://dx.doi.org/10.1155/2012/982396

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