Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.

Bibliographic Details
Main Authors: Birgit Jauk, Tetiana Pernat, C. Oliver Kappe
Format: Article
Language:English
Published: MDPI AG 2000-03-01
Series:Molecules
Subjects:
Dihydropyrimidines
Biginelli reaction
isomünchnones
1
3-dipolar cycloaddition reactions
AM1 calculations
conformation
Online Access:http://www.mdpi.com/1420-3049/5/3/227/
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spelling doaj-c1ecd51953284033916f25ba3e15708b2020-11-24T23:33:42ZengMDPI AGMolecules1420-30492000-03-015322723910.3390/50300227Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926Birgit JaukTetiana PernatC. Oliver KappeA conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.http://www.mdpi.com/1420-3049/5/3/227/DihydropyrimidinesBiginelli reactionisomünchnones13-dipolar cycloaddition reactionsAM1 calculationsconformation
collection DOAJ
language English
format Article
sources DOAJ
author Birgit Jauk
Tetiana Pernat
C. Oliver Kappe
spellingShingle Birgit Jauk
Tetiana Pernat
C. Oliver Kappe
Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
Molecules
Dihydropyrimidines
Biginelli reaction
isomünchnones
1
3-dipolar cycloaddition reactions
AM1 calculations
conformation
author_facet Birgit Jauk
Tetiana Pernat
C. Oliver Kappe
author_sort Birgit Jauk
title Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
title_short Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
title_full Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
title_fullStr Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
title_full_unstemmed Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
title_sort design and synthesis of a conformationally rigid mimic of the dihydropyrimidine calcium channel modulator sq 32,926
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2000-03-01
description A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
topic Dihydropyrimidines
Biginelli reaction
isomünchnones
1
3-dipolar cycloaddition reactions
AM1 calculations
conformation
url http://www.mdpi.com/1420-3049/5/3/227/
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AT tetianapernat designandsynthesisofaconformationallyrigidmimicofthedihydropyrimidinecalciumchannelmodulatorsq32926
AT coliverkappe designandsynthesisofaconformationallyrigidmimicofthedihydropyrimidinecalciumchannelmodulatorsq32926
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