Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.

Bibliographic Details
Main Authors:	Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13965-x

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spelling	doaj-c1f734a4d6574c6d950eb373c2f183522021-05-11T08:41:09ZengNature Publishing GroupNature Communications2041-17232020-01-0111111810.1038/s41467-019-13965-xGenome-wide CRISPR screen identifies host dependency factors for influenza A virus infectionBo Li0Sara M. Clohisey1Bing Shao Chia2Bo Wang3Ang Cui4Thomas Eisenhaure5Lawrence D. Schweitzer6Paul Hoover7Nicholas J. Parkinson8Aharon Nachshon9Nikki Smith10Tim Regan11David Farr12Michael U. Gutmann13Syed Irfan Bukhari14Andrew Law15Maya Sangesland16Irit Gat-Viks17Paul Digard18Shobha Vasudevan19Daniel Lingwood20David H. Dockrell21John G. Doench22J. Kenneth Baillie23Nir Hacohen24Harvard University Virology Program, Harvfvard Medical SchoolRoslin Institute, University of EdinburghHarvard University Virology Program, Harvfvard Medical SchoolRoslin Institute, University of EdinburghBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardRoslin Institute, University of EdinburghSchool of Molecular Cell Biology and Biotechnology, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv UniversityRoslin Institute, University of EdinburghRoslin Institute, University of EdinburghRoslin Institute, University of EdinburghSchool of informatics, University of EdinburghCenter for Cancer Research, Massachusetts General hospital, Harvard Medical SchoolRoslin Institute, University of EdinburghThe Ragon Institute of Massachusetts General Hospital, MIT and Harvard UniversityBroad Institute of MIT and HarvardRoslin Institute, University of EdinburghCenter for Cancer Research, Massachusetts General hospital, Harvard Medical SchoolThe Ragon Institute of Massachusetts General Hospital, MIT and Harvard UniversityMRC Center for Inflammation Research, University of EdinburghBroad Institute of MIT and HarvardRoslin Institute, University of EdinburghBroad Institute of MIT and HarvardHere, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.https://doi.org/10.1038/s41467-019-13965-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen
spellingShingle	Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection Nature Communications
author_facet	Bo Li Sara M. Clohisey Bing Shao Chia Bo Wang Ang Cui Thomas Eisenhaure Lawrence D. Schweitzer Paul Hoover Nicholas J. Parkinson Aharon Nachshon Nikki Smith Tim Regan David Farr Michael U. Gutmann Syed Irfan Bukhari Andrew Law Maya Sangesland Irit Gat-Viks Paul Digard Shobha Vasudevan Daniel Lingwood David H. Dockrell John G. Doench J. Kenneth Baillie Nir Hacohen
author_sort	Bo Li
title	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_short	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_full	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_fullStr	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_full_unstemmed	Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
title_sort	genome-wide crispr screen identifies host dependency factors for influenza a virus infection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.
url	https://doi.org/10.1038/s41467-019-13965-x
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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

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