Particle Formation by Supercritical Fluid Extraction and Expansion Process

Particle Formation by Supercritical Fluid Extraction and Expansion Process

Supercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chines...

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Main Authors: Sujuan Pan, Junbo Zhou, Haiting Li, Can Quan
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2013/538584
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spelling doaj-c1fc0c33baee4c75ade6202cdfe650502020-11-25T01:17:56ZengHindawi LimitedThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/538584538584Particle Formation by Supercritical Fluid Extraction and Expansion ProcessSujuan Pan0Junbo Zhou1Haiting Li2Can Quan3Engineering Research Center for Polymer Processing Equipment, Ministry of Education, School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaEngineering Research Center for Polymer Processing Equipment, Ministry of Education, School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaEngineering Research Center for Polymer Processing Equipment, Ministry of Education, School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaDivision of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100013, ChinaSupercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chinese herbal medicine. Supercritical fluid extraction is a green separation technology, which has been developed for decades and widely applied in traditional Chinese medicines or natural active components. In this paper, a SFEE patented instrument was firstly built up and controlled by LABVIEW work stations. Stearic acid was used to verify the SFEE process at optimized condition; via adjusting the preexpansion pressure and temperature one can get different sizes of particles. Furthermore, stearic acid was purified during the SFEE process with HPLC-ELSD detecting device; purity of stearic acid increased by 19%, and the device can purify stearic acid.http://dx.doi.org/10.1155/2013/538584
collection DOAJ
language English
format Article
sources DOAJ
author Sujuan Pan
Junbo Zhou
Haiting Li
Can Quan
spellingShingle Sujuan Pan
Junbo Zhou
Haiting Li
Can Quan
Particle Formation by Supercritical Fluid Extraction and Expansion Process
The Scientific World Journal
author_facet Sujuan Pan
Junbo Zhou
Haiting Li
Can Quan
author_sort Sujuan Pan
title Particle Formation by Supercritical Fluid Extraction and Expansion Process
title_short Particle Formation by Supercritical Fluid Extraction and Expansion Process
title_full Particle Formation by Supercritical Fluid Extraction and Expansion Process
title_fullStr Particle Formation by Supercritical Fluid Extraction and Expansion Process
title_full_unstemmed Particle Formation by Supercritical Fluid Extraction and Expansion Process
title_sort particle formation by supercritical fluid extraction and expansion process
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2013-01-01
description Supercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chinese herbal medicine. Supercritical fluid extraction is a green separation technology, which has been developed for decades and widely applied in traditional Chinese medicines or natural active components. In this paper, a SFEE patented instrument was firstly built up and controlled by LABVIEW work stations. Stearic acid was used to verify the SFEE process at optimized condition; via adjusting the preexpansion pressure and temperature one can get different sizes of particles. Furthermore, stearic acid was purified during the SFEE process with HPLC-ELSD detecting device; purity of stearic acid increased by 19%, and the device can purify stearic acid.
url http://dx.doi.org/10.1155/2013/538584
work_keys_str_mv AT sujuanpan particleformationbysupercriticalfluidextractionandexpansionprocess
AT junbozhou particleformationbysupercriticalfluidextractionandexpansionprocess
AT haitingli particleformationbysupercriticalfluidextractionandexpansionprocess
AT canquan particleformationbysupercriticalfluidextractionandexpansionprocess
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