The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects
The present review focuses on the multi-faceted effects of curcumin on the neurobiology glioblastoma multiforme (GBM), with a special emphasis on autophagy (ATG)-dependent molecular pathways activated by such a natural polyphenol. This is consistent with the effects of curcumin in a variety of exper...
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doaj-c1ffafee135d4e89bfde00660f7af33b2020-11-25T03:56:57ZengMDPI AGMolecules1420-30492020-10-01254839483910.3390/molecules25204839The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent EffectsLarisa Ryskalin0Francesca Biagioni1Carla L. Busceti2Gloria Lazzeri3Alessandro Frati4Francesco Fornai5Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, ItalyI.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, ItalyI.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, ItalyI.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, ItalyThe present review focuses on the multi-faceted effects of curcumin on the neurobiology glioblastoma multiforme (GBM), with a special emphasis on autophagy (ATG)-dependent molecular pathways activated by such a natural polyphenol. This is consistent with the effects of curcumin in a variety of experimental models of neurodegeneration, where the molecular events partially overlap with GBM. In fact, curcumin broadly affects various signaling pathways, which are similarly affected in cell degeneration and cell differentiation. The antitumoral effects of curcumin include growth inhibition, cell cycle arrest, anti-migration and anti-invasion, as well as chemo- and radio-sensitizing activity. Remarkably, most of these effects rely on mammalian target of rapamycin (mTOR)-dependent ATG induction. In addition, curcumin targets undifferentiated and highly tumorigenic GBM cancer stem cells (GSCs). When rescuing ATG with curcumin, the tumorigenic feature of GSCs is suppressed, thus counteracting GBM establishment and growth. It is noteworthy that targeting GSCs may also help overcome therapeutic resistance and reduce tumor relapse, which may lead to a significant improvement of GBM prognosis. The present review focuses on the multi-faceted effects of curcumin on GBM neurobiology, which represents an extension to its neuroprotective efficacy.https://www.mdpi.com/1420-3049/25/20/4839curcuma longanatural polyphenolsneuroprotectionanti-cancer effectsglioblastoma stem-like cellsautophagy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Larisa Ryskalin Francesca Biagioni Carla L. Busceti Gloria Lazzeri Alessandro Frati Francesco Fornai |
spellingShingle |
Larisa Ryskalin Francesca Biagioni Carla L. Busceti Gloria Lazzeri Alessandro Frati Francesco Fornai The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects Molecules curcuma longa natural polyphenols neuroprotection anti-cancer effects glioblastoma stem-like cells autophagy |
author_facet |
Larisa Ryskalin Francesca Biagioni Carla L. Busceti Gloria Lazzeri Alessandro Frati Francesco Fornai |
author_sort |
Larisa Ryskalin |
title |
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects |
title_short |
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects |
title_full |
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects |
title_fullStr |
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects |
title_full_unstemmed |
The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects |
title_sort |
multi-faceted effect of curcumin in glioblastoma from rescuing cell clearance to autophagy-independent effects |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-10-01 |
description |
The present review focuses on the multi-faceted effects of curcumin on the neurobiology glioblastoma multiforme (GBM), with a special emphasis on autophagy (ATG)-dependent molecular pathways activated by such a natural polyphenol. This is consistent with the effects of curcumin in a variety of experimental models of neurodegeneration, where the molecular events partially overlap with GBM. In fact, curcumin broadly affects various signaling pathways, which are similarly affected in cell degeneration and cell differentiation. The antitumoral effects of curcumin include growth inhibition, cell cycle arrest, anti-migration and anti-invasion, as well as chemo- and radio-sensitizing activity. Remarkably, most of these effects rely on mammalian target of rapamycin (mTOR)-dependent ATG induction. In addition, curcumin targets undifferentiated and highly tumorigenic GBM cancer stem cells (GSCs). When rescuing ATG with curcumin, the tumorigenic feature of GSCs is suppressed, thus counteracting GBM establishment and growth. It is noteworthy that targeting GSCs may also help overcome therapeutic resistance and reduce tumor relapse, which may lead to a significant improvement of GBM prognosis. The present review focuses on the multi-faceted effects of curcumin on GBM neurobiology, which represents an extension to its neuroprotective efficacy. |
topic |
curcuma longa natural polyphenols neuroprotection anti-cancer effects glioblastoma stem-like cells autophagy |
url |
https://www.mdpi.com/1420-3049/25/20/4839 |
work_keys_str_mv |
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