Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012
It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source–sink model for a Latin American country. Viruses were obtained during 2010–2012 from influenza surveillance cohor...
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2015-08-01
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doaj-c20d90a4da834e4c86f37553c35e2cdd2020-11-24T21:52:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-08-012181330133810.3201/eid2108.150084Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012Simon PollettMartha I. NelsonMatthew R. KasperYeny TinocoMark SimonsCandice RomeroMarita SilvaXudong LinRebecca A. HalpinNadia B. FedorovaTimothy B. StockwellDavid WentworthEdward C. HolmesDaniel G. BauschIt remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source–sink model for a Latin American country. Viruses were obtained during 2010–2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains.https://wwwnc.cdc.gov/eid/article/21/8/15-0084_articlePeruH3N2influenza virusevolutionvirusesphylogeography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon Pollett Martha I. Nelson Matthew R. Kasper Yeny Tinoco Mark Simons Candice Romero Marita Silva Xudong Lin Rebecca A. Halpin Nadia B. Fedorova Timothy B. Stockwell David Wentworth Edward C. Holmes Daniel G. Bausch |
spellingShingle |
Simon Pollett Martha I. Nelson Matthew R. Kasper Yeny Tinoco Mark Simons Candice Romero Marita Silva Xudong Lin Rebecca A. Halpin Nadia B. Fedorova Timothy B. Stockwell David Wentworth Edward C. Holmes Daniel G. Bausch Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 Emerging Infectious Diseases Peru H3N2 influenza virus evolution viruses phylogeography |
author_facet |
Simon Pollett Martha I. Nelson Matthew R. Kasper Yeny Tinoco Mark Simons Candice Romero Marita Silva Xudong Lin Rebecca A. Halpin Nadia B. Fedorova Timothy B. Stockwell David Wentworth Edward C. Holmes Daniel G. Bausch |
author_sort |
Simon Pollett |
title |
Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 |
title_short |
Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 |
title_full |
Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 |
title_fullStr |
Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 |
title_full_unstemmed |
Phylogeography of Influenza A(H3N2) Virus in Peru, 2010–2012 |
title_sort |
phylogeography of influenza a(h3n2) virus in peru, 2010–2012 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2015-08-01 |
description |
It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source–sink model for a Latin American country. Viruses were obtained during 2010–2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains. |
topic |
Peru H3N2 influenza virus evolution viruses phylogeography |
url |
https://wwwnc.cdc.gov/eid/article/21/8/15-0084_article |
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