| Summary: | Non-Hodgkin lymphomas of childhood represent a diverse group of neoplasms
with different clinical, pathological, immunophenotypical and genetic
features. A vast majority of childhood non-Hodgkin lymphomas could be
classified into one of the three major histological subgroups: mature B-cell
neoplasms, lymphoblastic lymphomas or anaplastic large cell lymphomas. Modern
therapeutic strategies lead to cure in more than 80% of patients. Conversely,
refractory diseases, as well as disease relapse convey a dismal prognosis.
This fact requires much better stratification based on prognostic markers
which would ideally recognize distinct groups of patients requiring different
therapeutic regimens. Defining novel diagnostic and prognostic markers should
improve diagnosis and prognosis as well as patient follow-up. It should also
allow introduction of individually tailored treatment regimens in selected
groups of patients with non-Hodgkin lymphomas, with the main goal of
improving treatment results and decreasing short- and long-term
complications. [Projekat Ministarstva nauke Republike Srbije, br. 41004]
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