A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity
Abstract Ophiocordyceps lanpingensis is an edible mushroom distributed over the south‐eastern part of the Tibet Plateau, which is also recognized as an effective ethnomedicine to alleviate diseases. This study explored the effects of a kind of Ophiocordyceps lanpingensis neutral polysaccharide (ONP)...
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doaj-c2221e9a5fda4293b25c77288f47ec592021-07-09T14:35:58ZengWileyFood Science & Nutrition2048-71772021-07-01973602361610.1002/fsn3.2317A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicityShubo Zhou0Yongchun Zhou1Jiaji Yu2Li Jiang3Yingying Xiang4Juan Wang5Yaxi Du6Xiuming Cui7Feng Ge8Yunnan Provincial Key Laboratory of Panax notoginseng Faculty of Life Science and Technology Kunming University of Science and Technology Kunming ChinaYunnan Cancer Center Molecular Diagnostics Center Yunnan Cancer Hospital & the Third Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Microbiology, Immunology & Molecular Genetics University of California Los Angeles CA USAYunnan Provincial Key Laboratory of Panax notoginseng Faculty of Life Science and Technology Kunming University of Science and Technology Kunming ChinaDepartment of Stomatology Yan’an Hospital Affiliated to Kunming Medical University Kunming ChinaYunnan Provincial Key Laboratory of Panax notoginseng Faculty of Life Science and Technology Kunming University of Science and Technology Kunming ChinaYunnan Cancer Center Molecular Diagnostics Center Yunnan Cancer Hospital & the Third Affiliated Hospital of Kunming Medical University Kunming ChinaYunnan Provincial Key Laboratory of Panax notoginseng Faculty of Life Science and Technology Kunming University of Science and Technology Kunming ChinaYunnan Provincial Key Laboratory of Panax notoginseng Faculty of Life Science and Technology Kunming University of Science and Technology Kunming ChinaAbstract Ophiocordyceps lanpingensis is an edible mushroom distributed over the south‐eastern part of the Tibet Plateau, which is also recognized as an effective ethnomedicine to alleviate diseases. This study explored the effects of a kind of Ophiocordyceps lanpingensis neutral polysaccharide (ONP) on RAW264.7 macrophages and cisplatin‐induced nephrotoxicity. The results showed that ONP relieved the inflammatory response of RAW264.7 macrophages by increasing the expression level of anti‐inflammatory factor IL‐10. Furthermore, ONP treatment significantly prolonged the survival of the mice treated by cisplatin through decelerating pathological progress and alleviating damaged functions of the kidneys. Compared with the cisplatin group, ONP reduced the oxidative stress of the renal cells and the expression levels of pro‐inflammatory factors. Apoptosis of renal cells was also weakened in the ONP treatment group. These findings indicated that ONP alleviated cisplatin nephrotoxicity mainly by inhibiting oxidative stress, inflammation, and apoptosis in the kidneys, underscoring the potential of ONP supplementation to alleviate the side effects of cisplatin chemotherapy.https://doi.org/10.1002/fsn3.2317cisplatinnephrotoxicityOphiocordycepspolysaccharide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shubo Zhou Yongchun Zhou Jiaji Yu Li Jiang Yingying Xiang Juan Wang Yaxi Du Xiuming Cui Feng Ge |
spellingShingle |
Shubo Zhou Yongchun Zhou Jiaji Yu Li Jiang Yingying Xiang Juan Wang Yaxi Du Xiuming Cui Feng Ge A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity Food Science & Nutrition cisplatin nephrotoxicity Ophiocordyceps polysaccharide |
author_facet |
Shubo Zhou Yongchun Zhou Jiaji Yu Li Jiang Yingying Xiang Juan Wang Yaxi Du Xiuming Cui Feng Ge |
author_sort |
Shubo Zhou |
title |
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
title_short |
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
title_full |
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
title_fullStr |
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
title_full_unstemmed |
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
title_sort |
neutral polysaccharide from ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity |
publisher |
Wiley |
series |
Food Science & Nutrition |
issn |
2048-7177 |
publishDate |
2021-07-01 |
description |
Abstract Ophiocordyceps lanpingensis is an edible mushroom distributed over the south‐eastern part of the Tibet Plateau, which is also recognized as an effective ethnomedicine to alleviate diseases. This study explored the effects of a kind of Ophiocordyceps lanpingensis neutral polysaccharide (ONP) on RAW264.7 macrophages and cisplatin‐induced nephrotoxicity. The results showed that ONP relieved the inflammatory response of RAW264.7 macrophages by increasing the expression level of anti‐inflammatory factor IL‐10. Furthermore, ONP treatment significantly prolonged the survival of the mice treated by cisplatin through decelerating pathological progress and alleviating damaged functions of the kidneys. Compared with the cisplatin group, ONP reduced the oxidative stress of the renal cells and the expression levels of pro‐inflammatory factors. Apoptosis of renal cells was also weakened in the ONP treatment group. These findings indicated that ONP alleviated cisplatin nephrotoxicity mainly by inhibiting oxidative stress, inflammation, and apoptosis in the kidneys, underscoring the potential of ONP supplementation to alleviate the side effects of cisplatin chemotherapy. |
topic |
cisplatin nephrotoxicity Ophiocordyceps polysaccharide |
url |
https://doi.org/10.1002/fsn3.2317 |
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