The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells

The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells

5-fluorouracil (5-FU) is one of the major components of many standard regimens for chemotherapy of colorectal cancer (CRC) and some other malignancies. Given the known relationship between thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) activity and 5-FU metabolism, this s...

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Bibliographic Details
Main Authors: Fakhraddin Naghibalhossaini, Marzieh Shefaghat, Amirata Mansouri, Hajar Jaberi, Mohsen Tatar, Ebrahim Eftekhar
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-01-01
Series:Acta Medica Iranica
Subjects:
5-Fluorouracil
Colorectal cancer
Chemotherapy resistance
Thymidylate synthase
MTHFR
Polymorphism
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/6258

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